Observational studyAging clinical and experimental research2024
Influence of serum uric acid on bone and fracture risk in postmenopausal women.
Observational study in Aging clinical and experimental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- The role of FOXO3 and Irisin in evaluating posterior cruciate ligament and knee functional recovery after surgical treatment of tibial avulsion fracture of the posterior cruciate ligament insertion.Journal of medical biochemistry · 2026Article
- Serum Uric Acid Levels in Older Adults: Associations With Clinical Outcomes and Implications for Reference Intervals in Those Aged 70 Years and Over.Arthritis care & research · 2026Article
- Construction of a nomogram prediction model for individualized prediction of vertebral compression fracture risk in postmenopausal osteoporosis population.Scientific reports · 2026Article
- The role of the neuro-immune-bone axis in osteoporosis: from bone remodeling imbalance to multi-system interactions.Frontiers in immunology · 2026Review
- Association between the serum uric acid to HDL cholesterol ratio and forearm bone mineral density in middle-aged and older adults.Frontiers in endocrinology · 2026Article
- Association of uric acid, calcium, and creatinine with bone mineral density in adults over 50: a cross-sectional study.Frontiers in endocrinology · 2026Article
- Sex-Stratified Association of Serum Uric Acid With Multisite Bone Mineral Density Among Inpatients With Type 2 Diabetes: A Cross-Sectional Study.Journal of diabetes research · 2026Article
- Relation of bone mineral density with fat infiltration of paraspinal muscles.Osteoporosis and sarcopenia · 2025Article
- The triangular relationship of serum uric acid, osteoporosis or osteopenia, and body mass index for men and postmenopausal women.Scientific reports · 2025Article
- The dual association of serum uric acid with the functional outcomes of patients after hip arthroplasty: 1-year follow-up study.Frontiers in surgery · 2025Article
- Serum uric acid/creatinine ratio and osteoporosis in the elderly: a NHANES study.Frontiers in medicine · 2025Article
- Relationship Between Body Composition and Hypertension in Postmenopausal Women with Osteoporosis-A Single-Center Cross-Sectional Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Multi-omics reveals circadian regulation of bone homeostasis by gut microbiota metabolites: mechanisms and chronotherapeutic implications.Frontiers in immunology · 2025Review
- Association of baseline osteocalcin and femoral neck bone mineral density in healthy women with future risk of fractures, cardiovascular disease, diabetes and death.Frontiers in endocrinology · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsUric acid has been associated with several metabolic conditions, including bone diseases. Our objective here was to consider the relationship between serum uric acid levels and various bone parameters (bone mineral density, ultrasonographic parameters, vitamin D, PTH and serum calcium), as well as the prevalence and risk of fragility fracture.
methodsAn observational and cross-sectional study carried out on 679 postmenopausal women, classified into 3 groups according to their serum uric acid levels, in whom bone densitometry, calcaneus ultrasounds, PTH, vitamin D and serum calcium analysis were done. Bone fractures were collected through the clinical history and lateral spinal X-ray.
resultsHigher uric acid levels were found in women with older age, high BMI, diabetes, and high blood pressure. Higher levels of PTH and serum calcium were also observed, but did not effect on vitamin D. Serum uric acid was positively related to densitometric and ultrasonic parameters and negatively associated with vertebral fractures.
conclusionsIn the population of postmenopausal women studied, sUA levels were correlated with BMD, BUA, and QUI-Stiffness, and this correlation was independent of age and BMI. In addition, sUA was associated with a decrease in vertebral fractures. These results imply a beneficial influence of sUA on bone metabolism, with both a quantitative and qualitative positive effect, reflected in the lower prevalence of vertebral fractures.
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