ArticleNature2024
Histone serotonylation regulates ependymoma tumorigenesis.
Abstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed.
- Platelet-derived serotonin epigenetically programs macrophage alternative activation to orchestrate type 2 airway inflammation.Cellular & molecular immunology · 2026Article
- Targeting the nervous system: Mechanistic insights into neuro-tumor communication and therapeutic opportunities.Acta pharmaceutica Sinica. B · 2026Review
- Post-translational modifications in metabolic reprogramming: implications for metabolic therapy and immunotherapy in cancer.Signal transduction and targeted therapy · 2026Review
- The impact of microbial metabolites on host chromatin and epigenetic regulation.Nature metabolism · 2026Review
- Remodelling the tumour microenvironment and beyond: ERO1A as a multifaceted regulator and emerging therapeutic target in cancer.Clinical and translational medicine · 2026Review
- The oocyte-enriched metabolite serotonin alleviates cellular senescence and aging phenotypes in the mouse.The EMBO journal · 2026Article
- Neurotransmitters in cancer: how receptor signaling and posttranslational modifications modulate tumor progression and offer new therapeutic targets.Cell communication and signaling : CCS · 2026Review
- Neuroendocrine tumours through an epigenetic lens: Emerging insights for diagnosis and treatment.Journal of neuroendocrinology · 2026Review
- Beyond neurotransmission: the roles of serotonylation in physiological and pathological processes.Cellular & molecular biology letters · 2026Review
- TGM2-mediated serotonylation of GPX4 confers ferroptosis resistance to promote gastric tumorigenesis.Cell discovery · 2026Article
- H3 dopaminylation and CaMKII modulate diffuse midline glioma response to CDK9 inhibition.bioRxiv : the preprint server for biology · 2026Article
- Serotonin Modulates Lineage Plasticity in Neuroendocrine Prostate Cancer via Epigenetic Reprogramming.Cancer discovery · 2026Article
- Unraveling the complexity of the histone code: implications for gene regulation and disease.Genome biology · 2026Review
- Quinone reductase 2bioRxiv : the preprint server for biology · 2026Article
- Monoaminylation in Human Health and Disease: State of the Field, Challenges, and Emerging Directions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Cancer neuroscience: signaling pathways and new therapeutic strategies for cancer.Signal transduction and targeted therapy · 2026Review
- Nervous and immune system crosstalk shapes cancer progression and treatment response.Discover oncology · 2026Review
- Review
- The impact of concomitant medications on treatment outcomes in patients with cancer receiving immune checkpoint inhibitors.Nature reviews. Cancer · 2026Review
- 5-HT reuptake blockade induces pyroptosis in BRAFCell reports. Medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors.
Hsiao-Chi ChenProgram in Cancer and Cell Biology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-7505-6119
Peihao HeProgram in Cancer and Cell Biology, Baylor College of Medicine, Houston, TX, USA.
Malcolm McDonaldCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.
Michael R WilliamsonCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-8049-4463
Srinidhi VaradharajanCenter of Excellence in Neuro-Oncology Sciences (CENOS), St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-2033-0758
Brittney LozziCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.
Junsung WooCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.
Dong-Joo ChoiCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.
Debosmita SardarCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-8158-2185
Emmet Huang-HobbsCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-2071-2588
Hua SunCenter of Excellence in Neuro-Oncology Sciences (CENOS), St. Jude Children's Research Hospital, Memphis, TN, USA.
Siri M IppaguntaCenter of Excellence in Neuro-Oncology Sciences (CENOS), St. Jude Children's Research Hospital, Memphis, TN, USA.
Antrix JainMass Spectrometry Proteomics Core, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-2815-3645
Ganesh RaoCenter for Cancer Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Thomas E MerchantDepartment of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-0412-6255
David W EllisonDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Jeffrey L NoebelsDepartment of Human and Molecular Genetics, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-2887-0839
Kelsey C BertrandDivision of Neuro-Oncology, Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Stephen C MackCenter of Excellence in Neuro-Oncology Sciences (CENOS), St. Jude Children's Research Hospital, Memphis, TN, USA. stephen.mack@stjude.org.ORCID 0000-0001-9620-4742
Benjamin DeneenProgram in Cancer and Cell Biology, Baylor College of Medicine, Houston, TX, USA. deneen@bcm.edu.ORCID 0000-0002-6335-1081
Funding
Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Michael M Ittmann · 2007 to 2026
$73.9MPreclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sandesh Chakravarthy Sreenath Nagamani, David Loren Nelson · 2020 to 2026
$9.9MTraining In Cell and Gene TherapyT32HL092332 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI MALCOLM K. BRENNER, Bruno Di Stefano · 2008 to 2026
$6.9MIntegrative bioinformatics and functional characterization of oncogenic driver aberrations in cancerU01CA217842 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DENEEN, BENJAMIN, MILLS, GORDON B. · 2017 to 2021
$3.6MMOLECULAR DISSECTION OF SEIZURE MICROENVIRONMENT IN MALIGNANT GLIOMAR01CA223388 · NCI · BAYLOR COLLEGE OF MEDICINE · PI DENEEN, BENJAMIN, NOEBELS, JEFFREY · 2018 to 2022
$3.5MAstrocyte Transcriptional Dependencies in Brain CircuitsR35NS132230 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI Benjamin Deneen · 2023 to 2026
$3.5MTargeting tumor and T cell DNA methylomes to improve CAR T cell therapies for diffuse midline gliomaU01CA281823 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Giedre Krenciute, Stephen C Mack · 2023 to 2026
$2.8MRole of FACT in ZFTA-RelA fusion driven ependymomaR01CA280203 · NCI · OHIO STATE UNIVERSITY · PI Stephen C Mack, Monica Venere · 2023 to 2026
$2.8MDeciphering the Role of Aberrant Endogenous Retroviral Expression in Onco-histone Driven GliomaR01NS116361 · NINDS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Stephen C Mack · 2021 to 2026
$2.5MTranscriptional Regulation in ZFTA-RELA EpendymomaR01CA284455 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Benjamin Deneen, Stephen C Mack · 2023 to 2026
$2.5MCellular and Molecular Mechanisms of GBM InfiltrationR01NS124093 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI Benjamin Deneen, Ganesh Rao · 2022 to 2026
$1.6MAstrocyte transcriptional responses to neuronal activity in the olfactory bulbK99DC019668 · NIDCD · BAYLOR COLLEGE OF MEDICINE · PI SARDAR, DEBOSMITA · 2022 to 2023
$198kAmerican Heart Association-American Stroke Association 23POST1019413NCI NIH HHS F31 CA243382NCI NIH HHS P30 CA125123NCI NIH HHS R01 CA223388NCI NIH HHS R01 CA280203NCI NIH HHS R01 CA284455NCI NIH HHS U01 CA217842NCI NIH HHS U01 CA281823NHLBI NIH HHS T32 HL092332NICHD NIH HHS P50 HD103555NIDCD NIH HHS K99 DC019668NINDS NIH HHS R01 NS116361NINDS NIH HHS R01 NS124093NINDS NIH HHS R35 NS132230
Abstract
Bidirectional communication between tumours and neurons has emerged as a key facet of the tumour microenvironment that drives malignancy
Indexed as
CarcinogenesisEpendymomaHistonesAnimalsBrain NeoplasmsCell Line, TumorChromatinDisease ProgressionDNA-Binding ProteinsEpigenesis, GeneticFemaleGene Expression Regulation, NeoplasticHumansMaleMiceSerotonergic NeuronsChromatinDNA-Binding ProteinsETV5 protein, humanHistonesSerotoninTranscription Factors
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.