Evidence map›Paper›PMID 39085606›Full record

ArticleNature2024

Dopamine biases decisions by limiting temporal integration.

Aditya K Gautham, Lauren E Miner, Marco N Franco, Stephen C Thornquist, Michael A Crickmore

Abstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. A genetic model of copulatory wounding inbioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Time-of-day modulation in mosquito response persistence to carbon dioxide is controlled by Pigment-Dispersing Factor.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Article
  10. Article
  11. Slow-Timescale Regulation of Dopamine Release and Mating Drive Over Days.bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aditya K GauthamF. M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Lauren E MinerF. M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-3756-3248
Marco N FrancoF. M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Stephen C ThornquistF. M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. thornquist@rockefeller.edu.ORCID 0000-0003-2693-4971
Michael A CrickmoreF. M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. michael.crickmore@childrens.harvard.edu.ORCID 0000-0002-7175-4745

Funding

Circuit principles of demotivation in the decision to switch behaviorsR01NS111441 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI CRICKMORE, MICHAEL A · 2019 to 2023
$2.0M
Mechanisms of interval timingR01GM134222 · NIGMS · BOSTON CHILDREN'S HOSPITAL · PI CRICKMORE, MICHAEL A · 2019 to 2022
$1.9M
NIGMS NIH HHS R01 GM134222NINDS NIH HHS R01 NS111441
6 · The paper itself

Abstract

Motivations bias our responses to stimuli, producing behavioural outcomes that match our needs and goals. Here we describe a mechanism behind this phenomenon: adjusting the time over which stimulus-derived information is permitted to accumulate towards a decision. As a Drosophila copulation progresses, the male becomes less likely to continue mating through challenges

Indexed as

CopulationDecision MakingDopamineDrosophila melanogasterAnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2FemaleMaleNeuronsTime FactorsCalcium-Calmodulin-Dependent Protein Kinase Type 2Dopamine

Identifiers

PMID39085606
PMCPMC12372616

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.