Evidence map›Paper›PMID 39085605›Full record

ArticleNature2024

Immunological memory diversity in the human upper airway.

Sydney I Ramirez, Farhoud Faraji, L Benjamin Hills, Paul G Lopez, Benjamin Goodwin, Hannah D Stacey, Henry J Sutton, Kathryn M Hastie, Erica Ollmann Saphire, Hyun Jik Kim and 5 more

Erratum issuedAbstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 73 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Mucosal immunity and vaccine development.Signal transduction and targeted therapy · 2026
    Pooled it
  2. Article
  3. Article
  4. Targeting T follicular helper cells for lifelong health.Nature reviews. Drug discovery · 2026
    Review
  5. Article
  6. Article
  7. Germinal center responses at barrier organ sites.Current opinion in immunology · 2026
    Review
  8. Review
  9. Article
  10. Review
  11. Distinct CD8iScience · 2026
    Article
  12. PD-1 Inhibits CD4+ TRM-Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Upper and Lower Respiratory Tract Compartmentalization in Pediatric Stem Cell Transplantation.American journal of respiratory cell and molecular biology · 2026
    Article
  18. Article
  19. Article
  20. Review

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Sydney I RamirezCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.ORCID 0000-0002-7166-5195
Farhoud Faraji *Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.ORCID 0000-0001-5078-813X
L Benjamin Hills *Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.
Paul G Lopez *Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.
Benjamin GoodwinCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.
Hannah D StaceyCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.
Henry J SuttonCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.ORCID 0000-0002-6472-7116
Kathryn M HastieCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.
Erica Ollmann SaphireCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.ORCID 0000-0002-1206-7451
Hyun Jik KimCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.ORCID 0000-0001-8631-928X
Sara MashoofCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.
Carol H YanDepartment of Otolaryngology-Head and Neck Surgery, University of California San Diego, La Jolla, CA, USA.
Adam S DeCondeDepartment of Otolaryngology-Head and Neck Surgery, University of California San Diego, La Jolla, CA, USA.
Gina LeviCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.
Shane CrottyCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA. shane@lji.org.ORCID 0000-0002-6484-6262

Funding

T follicular helper (Tfh) CD4+ T cell, germinal center, and antibody response dysfunction in human recurrent tonsillitisU19AI142742 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Shane P Crotty · 2019 to 2026
$32.8M
RESEARCH IN INFECTIOUS DISEASEST32AI007036 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIZET, VICTOR · 1985 to 2025
$9.2M
NIAID NIH HHS T32 AI007036NIAID NIH HHS U19 AI142742
6 · The paper itself

Abstract

The upper airway is an important site of infection, but immune memory in the human upper airway is poorly understood, with implications for COVID-19 and many other human diseases

Indexed as

Immunologic MemoryMemory B CellsMemory T CellsNasal MucosaNasopharynxSARS-CoV-2AdultCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCOVID-19Germinal CenterHumansImmunoglobulin APlasma CellsImmunoglobulin A

Identifiers

PMID39085605
PMCPMC11895801

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.