ArticleNature2024
Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants.
Abstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Epilepsy as a Multiscale Network Disorder: Integrating Precision Therapeutics and Emerging Experimental Platforms.Pharmaceutics · 2026Review
- Review
- Lipid bilayers determine allostery but not intrinsic affinity of cAMP to pacemaker channels.Nature communications · 2026Article
- (-)-Englerin A binding to human TRPC5 exposes an aromatic interaction network in channel activation.Nature communications · 2026Article
- The Nanodisc System for Investigating Protein-Lipid Interactions.Methods in molecular biology (Clifton, N.J.) · 2026Review
- Extracellular activation of HCN4 by a subtype-specific nanobody.Nature communications · 2025Article
- Extracellular salt bridge networks around S4 implicated in HCN channel gating and heart disease.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A propofol binding site in the voltage sensor domain mediates inhibition of HCN1 channel activity.Science advances · 2025Article
- Hyperpolarization-activated cyclic nucleotide-gated channels and epilepsy: genetics, circuits, and treatments.Frontiers in neurology · 2025Review
- Electrophysiology in neuropathic pain: a bibliometric analysis and literature review.Frontiers in neuroscience · 2025Review
- Unraveling the mechanisms of propofol-induced psychological dependence: a multi-omics approach linked to gut microbiota in hippocampal function.Frontiers in medicine · 2025Article
- Different fluorescent labels report distinct components of spHCN channel voltage sensor movement.The Journal of general physiology · 2024Article
Corrections and comments
- Commented on by
Authors and funding
11 authors.
Elizabeth D Kim *Department of Anesthesiology, Weill Cornell Medical College, New York, NY, USA.ORCID 0000-0002-6240-484X
Xiaoan Wu *Department of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, FL, USA.ORCID 0000-0003-2098-7298
Sangyun LeeDepartment of Anesthesiology, Weill Cornell Medical College, New York, NY, USA.ORCID 0000-0001-6272-4678
Gareth R TibbsDepartment of Anesthesiology, Weill Cornell Medical College, New York, NY, USA.ORCID 0000-0003-1494-5833
Kevin P CunninghamDepartment of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, FL, USA.ORCID 0000-0001-6772-0107
Eleonora Di ZanniDepartment of Anesthesiology, Weill Cornell Medical College, New York, NY, USA.ORCID 0000-0003-4564-2202
Marta E PerezDepartment of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, FL, USA.ORCID 0009-0005-7723-7860
Peter A GoldsteinDepartment of Anesthesiology, Weill Cornell Medical College, New York, NY, USA.ORCID 0000-0002-5973-9104
Alessio AccardiDepartment of Anesthesiology, Weill Cornell Medical College, New York, NY, USA.ORCID 0000-0002-6584-0102
H Peter LarssonDepartment of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, FL, USA. peter.larsson@liu.se.ORCID 0000-0002-1688-2525
Crina M NimigeanDepartment of Anesthesiology, Weill Cornell Medical College, New York, NY, USA. crn2002@med.cornell.edu.ORCID 0000-0002-6254-4447
Funding
Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARK Reid PHILIPS · 1985 to 2026
$83.1MStructural dynamics in cyclic nucleotide-modulated channelsR01GM124451 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI NIMIGEAN, CRINA M · 2017 to 2024
$3.2MAtomic basis for chloride channel and transporter gating and selectivityR01GM128420 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI ACCARDI, ALESSIO · 2019 to 2022
$1.5MActivation mechanism in HCN channels.R01GM139164 · NIGMS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BARRO-SORIA, RENE · 2020 to 2023
$1.5MUncovering Druggable Allosteric Sites in HCN ChannelsR01NS137561 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Crina M Nimigean · 2024 to 2026
$1.3MOptimization of an HCN1-Selective Inverse Agonist for the Treatment of Peripheral Neuropathic PainR42NS129370 · NINDS · AKELOS INC. · PI FOX, STEVEN R · 2022 to 2023
$699kIdentification of potential drug binding sites within allosteric networks in cyclic nucleotide modulated channelsF32GM145091 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI KIM, ELIZABETH DIONE · 2022 to 2023
$139kNCI NIH HHS P30 CA016087NIGMS NIH HHS F32 GM145091NIGMS NIH HHS R01 GM124451NIGMS NIH HHS R01 GM128420NIGMS NIH HHS R01 GM139164NINDS NIH HHS R01 NS137561NINDS NIH HHS R42 NS129370
Abstract
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels
Indexed as
EpilepsyHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsIon Channel GatingMutationPotassium ChannelsPropofolBinding SitesCryoelectron MicroscopyElectrophysiologyHEK293 CellsHumansMethionineModels, MolecularMovementPhenylalaninePolymorphism, GeneticHCN1 protein, humanHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsMethioninePhenylalaninePotassium ChannelsPropofol
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.