Evidence map›Paper›PMID 39085546›Full record

ArticleAnnals of surgical oncology2024

Margin Width and Local Recurrence in Patients with Phyllodes Tumors of the Breast.

Haydee Del Calvo, Yun Wu, Heather Y Lin, Elise F Nassif, Maria A Zarzour, B Ashleigh Guadagnolo, Kelly K Hunt, Isabelle Bedrosian, Heather A Lillemoe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of surgical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Comparative outcomes of conventional versus endoscopic-assisted surgery for breast phyllodes tumors: a single center retrospective cohort study.Translational breast cancer research : a journal focusing on translational research in breast cancer · 2026
    Article
  3. Review
  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Haydee Del CalvoDepartment of Surgery, Houston Methodist Hospital, Houston, TX, USA.
Yun WuDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Heather Y LinDepartment of Biostatistics, MD Anderson Cancer Center, Houston, TX, USA.
Elise F NassifDepartment of Sarcoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Maria A ZarzourDepartment of Sarcoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
B Ashleigh GuadagnoloDepartment of Sarcoma Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Kelly K HuntDepartment of Breast Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Isabelle BedrosianDepartment of Breast Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Heather A LillemoeDepartment of Breast Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. halillemoe@mdanderson.org.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

backgroundOptimal surgical margin width for patients with phyllodes tumors (PTs) of the breast remains debated. The aim of this study was to assess the influence of margin width on long-term local recurrence risk. PATIENTS AND

methodsThis was a single-institution retrospective review of patients with confirmed PT treated from 2008-2015. Margins were defined as positive (ink on tumor), narrow (no tumor at inked margin but < 10mm), or widely free (>/= 10mm). LR rates were estimated by the Kaplan-Meier method.

resultsAmong 117 female patients, histology included 55 (47%) benign, 29 (25%) borderline, and 33 (28%) malignant PT. Final margins were positive in 16 (14%), narrow in 32 (27%), widely free in 64 (55%), and unknown in 5 (4%) patients. Compared with margins > 10 mm, patients with positive and narrow margins had a higher LR risk [HR 10.57 (95% CI 2.48-45.02) and HR 5.66 (95% CI 1.19-26.99), respectively]. Among benign PTs, the 10-year LR-free rates were 100%, 94%, and 66% for widely negative, narrow, and positive margins, respectively (p = 0.056). For borderline/malignant PT, the 10-year LR-free rates were 93% and 57% for widely negative and narrow margins, respectively (p = 0.02), with no difference in LR between narrow and positive margin groups (p = 1.00).

conclusionsFor benign PTs, a margin of no ink on tumor appears sufficient to optimize local control. In patients with borderline or malignant PTs, achieving a wide surgical margin may remain important as narrower margins were associated with LR rates comparable to those with positive margins.

Indexed as

Breast NeoplasmsMargins of ExcisionNeoplasm Recurrence, LocalPhyllodes TumorAdolescentAdultAgedFemaleFollow-Up StudiesHumansMastectomyMiddle AgedPrognosisRetrospective StudiesSurvival RateYoung AdultBreast sarcomaLocal recurrenceLong-term outcomesPhyllodes tumorSurgical margin

Identifiers

PMID39085546
PMCPMC11913203

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