Evidence map›Paper›PMID 39085436›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2026

Factors associated with liberation from home mechanical ventilation and tracheostomy decannulation in infants and children with severe bronchopulmonary dysplasia.

Amit Agarwal, Winston M Manimtim, Stamatia Alexiou, Steven H Abman, Gangaram Akangire, Brianna C Aoyama, Eric D Austin, Christopher D Baker, Manvi Bansal, Sarah E Bauer and 17 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Amit AgarwalDivision of Pulmonary Medicine, Arkansas Children's Hospital and University of Arkansas for Medical Sciences, Little Rock, AR, USA. AgarwalAmit@uams.edu.ORCID http://orcid.org/0000-0002-9979-8483
Winston M ManimtimDivision of Neonatology, Children's Mercy-Kansas City and University of Missouri Kansas City School of Medicine, Kansas, MO, USA.ORCID http://orcid.org/0000-0001-8786-8512
Stamatia AlexiouDivision of Pulmonary Medicine, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, USA.
Steven H AbmanSection of Pulmonary and Sleep Medicine, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA.ORCID http://orcid.org/0000-0002-7292-2085
Gangaram AkangireDivision of Neonatology, Children's Mercy-Kansas City and University of Missouri Kansas City School of Medicine, Kansas, MO, USA.ORCID http://orcid.org/0000-0001-7796-7672
Brianna C AoyamaEudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, MD, USA.
Eric D AustinPulmonary Medicine, Vanderbilt University and Vanderbilt University Medical Center, Nashville, TN, USA.
Christopher D BakerSection of Pulmonary and Sleep Medicine, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA.ORCID http://orcid.org/0000-0002-1171-563X
Manvi BansalPulmonology and Sleep Medicine, Children's Hospital of Los Angeles, Los Angeles, CA, USA.
Sarah E BauerDivision of Pediatric Pulmonology, Allergy and Sleep Medicine, Riley Children's Hospital and Indiana University, Indianapolis, IN, USA.
A Ioana CristeaDivision of Pediatric Pulmonology, Allergy and Sleep Medicine, Riley Children's Hospital and Indiana University, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0002-9206-2190
Sara K DawsonDepartment of Pediatrics, Medical College of Wisconsin Milwaukee, Milwaukee, WI, USA.
Julie L FierroDivision of Pulmonary Medicine, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, USA.
Lystra P HaydenDivision of Pulmonary Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6874-0097
Jennifer K HenningfeldDepartment of Pediatrics, Medical College of Wisconsin Milwaukee, Milwaukee, WI, USA.
Jacob A KaslowPulmonary Medicine, Vanderbilt University and Vanderbilt University Medical Center, Nashville, TN, USA.
Khanh V LaiDivision of Pediatric Pulmonary and Sleep Medicine, University of Utah, Salt Lake City, UT, USA.
Jonathan C LevinDivision of Pulmonary Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-8422-791X
Robin L McKinneyDepartment of Pediatrics, Brown University School of Medicine, Providence, RI, USA.ORCID http://orcid.org/0000-0002-6107-0841
Audrey N MillerDivision of Neonatology, Nationwide Children's Hospital and Ohio State University, Columbus, OH, USA.ORCID http://orcid.org/0000-0001-6222-3515
Leif D NelinDivision of Neonatology, Nationwide Children's Hospital and Ohio State University, Columbus, OH, USA.ORCID http://orcid.org/0000-0002-3722-3035
Antonia P PopovaPediatric Pulmonology, University of Michigan, Ann Arbor, MI, USA.
Roopa SiddaiahPediatric Pulmonology, Penn State Health, Hershey, PA, USA.ORCID http://orcid.org/0000-0001-9184-3908
Michael C TracyDivision of Pediatric Pulmonary, Asthma and Sleep Medicine, Stanford University, Stanford, CA, USA.
Natalie M VillafrancoPulmonary Medicine, Texas Children's Hospital and Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0002-0168-1448
Sharon A McGrath-MorrowDivision of Pulmonary Medicine, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-1576-5394
Joseph M CollacoEudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, MD, USA.

Funding

Genetic Epidemiology of Respiratory Function in Former Preterm ChildrenK23HL136851 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI HAYDEN, LYSTRA P. · 2018 to 2022
$969k
Children's Hospital of Philadelphia (CHOP) N/AU.S. Department of Health & Human Services | National Institutes of Health (NIH) K23HL136851
6 · The paper itself

Abstract

objectiveTo identify factors associated with the timing of ventilator liberation and tracheostomy decannulation among infants with severe bronchopulmonary dysplasia (sBPD) who required chronic outpatient invasive ventilation. STUDY

designMulticenter retrospective study of 154 infants with sBPD on outpatient ventilators. Factors associated with ventilator liberation and decannulation were identified using Cox regression models and multilevel survival models.

resultsVentilation liberation and decannulation occurred at median ages of 27 and 49 months, respectively. Older age at transition to a portable ventilator and at discharge, higher positive end expiratory pressure, and multiple respiratory readmissions were associated with delayed ventilator liberation. Surgical management of gastroesophageal reflux was associated with later decannulation.

conclusionsVentilator liberation timing was impacted by longer initial admissions and higher ventilator pressure support needs, whereas decannulation timing was associated with more aggressive reflux management. Variation in the timing of events was primarily due to individual-level factors, rather than center-level factors.

Indexed as

Bronchopulmonary DysplasiaRespiration, ArtificialTracheostomyVentilator WeaningChild, PreschoolFemaleGastroesophageal RefluxHome Care ServicesHumansInfantInfant, NewbornMaleProportional Hazards ModelsRetrospective StudiesTime FactorsTracheostomy Decannulation

Identifiers

PMID39085436

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.