ArticleMolecular psychiatry2025
Cognitive and psychiatric relevance of dynamic functional connectivity states in a large (N > 10,000) children population.
Article in Molecular psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed.
- Individual-Level Associations of Cognition and Personality With Adolescent Mental Health Vary Across Brain and Environmental Profiles.bioRxiv : the preprint server for biology · 2026Article
- Dynamic Resting-State Network Markers of Disruptive Behavior Problems in Youth.Biological psychiatry global open science · 2026Article
- Robustness of NeuroMark-Derived Functional Networks to fMRI Spatial Normalization Across the Human Lifespan.bioRxiv : the preprint server for biology · 2026Article
- Activity Patterns in Relation to Dynamic Functional Network States: A Longitudinal Feasibility Study of Brain-Behavior Associations in Young Adults.Brain sciences · 2026Article
- Dynamic Functional Connectivity, Major Depression, and Suicidal Ideation in Children.Human brain mapping · 2026Article
- Prenatal Cannabis Exposure Shaping Altered Brain Connectivity: Neural Correlates of Cognitive and Mental Health Variability in Offspring.Research square · 2026Article
- When Randomness Becomes Rigid: Dynamic Connectivity Entropy and Symptom-Linked Network Dysfunction in Schizophrenia.bioRxiv : the preprint server for biology · 2026Article
- Cellular and molecular associations with intrinsic brain organization.Nature communications · 2025Article
- Cellular and molecular associations with intrinsic brain organization.bioRxiv : the preprint server for biology · 2025Article
- Limited generalizability of dynamic fMRI correlates of adolescent rumination.Nature. Mental health · 2025Article
- Regularized CCA identifies sex-specific brain-behavior associations in adolescent psychopathology.Translational psychiatry · 2025Article
- Deep Learning of Brain-Behavior Dimensions Identifies Transdiagnostic Biotypes in Youth with ADHD and Anxiety Disorders.bioRxiv : the preprint server for biology · 2025Article
- Neural flexibility in metabolic demand dynamics reveals sex-specific differences and supports cognition in late childhood.bioRxiv : the preprint server for biology · 2025Article
- Limited generalizability of dynamic fMRI correlates of adolescent rumination.bioRxiv : the preprint server for biology · 2025Article
- Modeling Temporal Dependencies in Brain Functional Connectivity to Identify Autism Spectrum Disorders Based on Heterogeneous rs-fMRI Data.Experimental neurobiology · 2025Article
- Dynamic functional connectivity signatures of focused attention on the breath in adolescents.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Dynamic fluctuations of intrinsic brain activity are associated with consistent topological patterns in puberty and are biomarkers of neural maturation.Network neuroscience (Cambridge, Mass.) · 2025Article
- Neurodevelopmental subtypes of functional brain organization in the ABCD study using a rigorous analytic framework.NeuroImage · 2024Article
- Neurodevelopmental Subtypes of Functional Brain Organization in the ABCD Study Using a Rigorous Analytic Framework.bioRxiv : the preprint server for biology · 2024Article
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Abstract
Children's brains dynamically adapt to the stimuli from the internal state and the external environment, allowing for changes in cognitive and mental behavior. In this work, we performed a large-scale analysis of dynamic functional connectivity (DFC) in children aged 9~11 years, investigating how brain dynamics relate to cognitive performance and mental health at an early age. A hybrid independent component analysis framework was applied to the Adolescent Brain Cognitive Development (ABCD) data containing 10,988 children. We combined a sliding-window approach with k-means clustering to identify five brain states with distinct DFC patterns. Interestingly, the occurrence of a strongly connected state with the most within-network synchrony and the anticorrelations between networks, especially between the sensory networks and between the cerebellum and other networks, was negatively correlated with cognitive performance and positively correlated with dimensional psychopathology in children. Meanwhile, opposite relationships were observed for a DFC state showing integration of sensory networks and antagonism between default-mode and sensorimotor networks but weak segregation of the cerebellum. The mediation analysis further showed that attention problems mediated the effect of DFC states on cognitive performance. This investigation unveils the neurological underpinnings of DFC states, which suggests that tracking the transient dynamic connectivity may help to characterize cognitive and mental problems in children and guide people to provide early intervention to buffer adverse influences.
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