Evidence map›Paper›PMID 39085199›Full record

ArticleNature communications2024

Single-cell profiling identifies a CD8

Pulak R Nath, Mary Maclean, Vijay Nagarajan, Jung Wha Lee, Mehmet Yakin, Aman Kumar, Hadi Nadali, Brian Schmidt, Koray D Kaya, Shilpa Kodati and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Pulak R NathClinical and Translational Immunology Unit, Laboratory of Immunology, NEI, NIH, Bethesda, USA. hellopran2000@gmail.com.ORCID 0000-0001-9643-5217
Mary MacleanClinical and Translational Immunology Unit, Laboratory of Immunology, NEI, NIH, Bethesda, USA.
Vijay NagarajanClinical and Translational Immunology Unit, Laboratory of Immunology, NEI, NIH, Bethesda, USA.ORCID 0000-0003-2455-7172
Jung Wha LeeClinical and Translational Immunology Unit, Laboratory of Immunology, NEI, NIH, Bethesda, USA.
Mehmet YakinClinical and Translational Immunology Unit, Laboratory of Immunology, NEI, NIH, Bethesda, USA.
Aman KumarClinical and Translational Immunology Unit, Laboratory of Immunology, NEI, NIH, Bethesda, USA.
Hadi NadaliClinical and Translational Immunology Unit, Laboratory of Immunology, NEI, NIH, Bethesda, USA.
Brian SchmidtNIH Intramural Sequencing Center, NIH, Rockville, USA.
Koray D KayaMedical Genetics and Ophthalmic Genomics Unit, NEI, NIH, Bethesda, USA.
Shilpa KodatiClinical and Translational Immunology Unit, Laboratory of Immunology, NEI, NIH, Bethesda, USA.
Alice YoungNIH Intramural Sequencing Center, NIH, Rockville, USA.
Rachel R CaspiImmunoregulation Section, Laboratory of Immunology, NEI, NIH, Bethesda, USA.ORCID 0000-0002-7140-7671
Jonas J W KuiperDepartment of Ophthalmology, University Medical Center Utrecht, University of Utrecht, Utrecht, Netherlands. j.j.w.kuiper@umcutrecht.nl.ORCID 0000-0002-5370-6395
H Nida SenClinical and Translational Immunology Unit, Laboratory of Immunology, NEI, NIH, Bethesda, USA.

Funding

Genetic, Cellular and Molecular Mechanisms in Autoimmunity to RetinaZIAEY000184 · NEI · NATIONAL EYE INSTITUTE · PI CASPI, RACHEL R. · 2009 to 2025
$51.7M
Studies of Ocular inflammation: Translational ResearchZIAEY000556 · NEI · NATIONAL EYE INSTITUTE · PI CASPI, RACHEL R. · 2017 to 2025
$11.3M
Intramural NIH HHS ZIA EY000556
6 · The paper itself

Abstract

Birdshot chorioretinopathy is an inflammatory eye condition strongly associated with MHC-I allele HLA-A29. The striking association with MHC-I suggests involvement of T cells, whereas natural killer (NK) cell involvement remains largely unstudied. Here we show that HLA-A29-positive birdshot chorioretinopathy patients have a skewed NK cell pool containing expanded CD16 positive NK cells which produce more proinflammatory cytokines. These NK cells contain populations that express CD8A which is involved in MHC-I recognition on target cells, display gene signatures indicative of high cytotoxic activity (GZMB, PRF1 and ISG15), and signaling through NK cell receptor CD244 (SH2D1B). Long-term monitoring of a cohort of birdshot chorioretinopathy patients with active disease identifies a population of CD8

Indexed as

Birdshot ChorioretinopathyHLA-A AntigensKiller Cells, NaturalSignaling Lymphocytic Activation Molecule FamilySingle-Cell AnalysisAdultCD8 AntigensChorioretinitisCytokinesFemaleGPI-Linked ProteinsHumansMaleMiddle AgedPerforinReceptors, IgGCD244 protein, humanCD8 antigen, alpha chainCD8 AntigensCytokinesFCGR3B protein, humanGPI-Linked ProteinsHLA-A29 antigenHLA-A AntigensPerforinPRF1 protein, humanReceptors, IgGSignaling Lymphocytic Activation Molecule Family

Identifiers

PMID39085199
PMCPMC11291632

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.