Evidence map›Paper›PMID 39085069›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Requirement of Repeated Serum VEGF Measurements in POEMS Syndrome.

Taichi Nomura, Ikuko Iwata, Katsuki Eguchi, Shintaro Fujii, Takashi Inoue, Monami Tarisawa, Takashi Ishio, Yuichiro Toyama, Hisashi Uwatoko, Shinichi Shirai and 3 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Taichi NomuraDepartment of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
Ikuko IwataDepartment of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
Katsuki EguchiDepartment of Neurology, Hokuyukai Neurological Hospital, Japan.
Shintaro FujiiDepartment of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
Takashi InoueDepartment of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
Monami TarisawaDepartment of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
Takashi IshioDepartment of Hematology, Sapporo Kosei General Hospital, Japan.
Yuichiro ToyamaDepartment of Neurology, Sapporo Kosei General Hospital, Japan.
Hisashi UwatokoDepartment of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
Shinichi ShiraiDepartment of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
Masaaki MatsushimaDepartment of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
Hiroaki YaguchiDepartment of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
Ichiro YabeDepartment of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

POEMS syndrome is often associated with a poor prognosis. Elevated serum vascular endothelial growth factor (sVEGF) is a useful diagnostic marker with high sensitivity and specificity. However, the relationship between sVEGF elevation and polyneuropathy in POEMS syndrome remains controversial. We herein report a case of polyneuropathy without sVEGF elevation at the first admission. However, at 21 months after the onset, the patient tested positive for sVEGF and was diagnosed with POEMS syndrome. Therefore, it is important to repeatedly measure sVEGF levels in patients with polyneuropathy with an atypical course when POEMS syndrome is suspected, even if the initial sVEGF level is normal.

Indexed as

POEMS SyndromeVascular Endothelial Growth Factor ABiomarkersHumansBiomarkersVascular Endothelial Growth Factor AVEGFA protein, humanPOEMS syndromepolyneuropathyvascular endothelial growth factor

Identifiers

PMID39085069
PMCPMC11949677

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.