Evidence map›Paper›PMID 39084875›Full record

ArticleLife science alliance2024

Differential roles of lysosomal cholesterol transporters in the development of

Amin Guo, Qi Wu, Xin Yan, Kanghua Chen, Yuxiang Liu, Dingfa Liang, Yuxiao Yang, Qunfeng Luo, Mingtao Xiong, Yong Yu and 2 more

Abstract read
In one paragraph

Article in Life science alliance, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Amin GuoSchool of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, China.
Qi WuSchool of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, China.
Xin YanSchool of Life Sciences, Nanchang University, Nanchang, China.
Kanghua ChenSchool of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, China.
Yuxiang LiuSchool of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, China.ORCID 0000-0001-5115-2563
Dingfa LiangQueen Mary School of Nanchang University, Jiangxi Medical College, Nanchang, China.ORCID 0009-0009-3754-315X
Yuxiao YangSchool of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, China.
Qunfeng LuoSchool of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, China.ORCID 0000-0002-4201-2961
Mingtao XiongInstitute of Biomedical Innovation, Jiangxi Medical College, Nanchang University, Nanchang, China.
Yong YuState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China.ORCID 0000-0002-9821-9726
Erkang FeiInstitute of Biomedical Innovation, Jiangxi Medical College, Nanchang University, Nanchang, China.ORCID 0000-0002-3581-9521
Fei ChenSchool of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, China feichen@ncu.edu.cn.ORCID 0009-0005-5378-7606

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440
6 · The paper itself

Abstract

Cholesterol homeostasis in neurons is critical for synapse formation and maintenance. Neurons with impaired cholesterol uptake undergo progressive synapse loss and eventual degeneration. To investigate the molecular mechanisms of neuronal cholesterol homeostasis and its role during synapse development, we studied motor neurons of

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsCholesterolLysosomesAnimalsHomeostasisMembrane Transport ProteinsMotor NeuronsNeuromuscular JunctionSynapsesCaenorhabditis elegans ProteinsCholesterolMembrane Transport Proteins

Identifiers

PMID39084875
PMCPMC11291935

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.