Evidence map›Paper›PMID 39084612›Full record

ArticleAnalytical chemistry2024

Blending Samples to Increase Accuracy and Precision of

Anders Bay Nord, Helen Lindqvist, Millie Rådjursöga, Anna Winkvist, B Göran Karlsson, Daniel Malmodin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anders Bay NordSwedish NMR Centre at the University of Gothenburg, P.O. Box 465, SE-405 30 Gothenburg, Sweden.ORCID 0000-0001-8704-5129
Helen LindqvistDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, P.O. Box 459, SE-405 30 Gothenburg, Sweden.
Millie RådjursögaSwedish NMR Centre at the University of Gothenburg, P.O. Box 465, SE-405 30 Gothenburg, Sweden.
Anna WinkvistDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, P.O. Box 459, SE-405 30 Gothenburg, Sweden.
B Göran KarlssonSwedish NMR Centre at the University of Gothenburg, P.O. Box 465, SE-405 30 Gothenburg, Sweden.
Daniel MalmodinSwedish NMR Centre at the University of Gothenburg, P.O. Box 465, SE-405 30 Gothenburg, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Urine is an equally attractive biofluid for metabolomics analysis, as it is a challenging matrix analytically. Accurate urine metabolite concentration estimates by Nuclear Magnetic Resonance (NMR) are hampered by pH and ionic strength differences between samples, resulting in large peak shift variability. Here we show that calculating the spectra of original samples from mixtures of samples using linear algebra reduces the shift problems and makes various error estimates possible. Since the use of two-dimensional (2D) NMR to confirm metabolite annotations is effectively impossible to employ on every sample of large sample sets, stabilization of metabolite peak positions increases the confidence in identifying metabolites, avoiding the pitfall of oranges-to-apples comparisons.

Indexed as

MetabolomicsHumansMagnetic Resonance SpectroscopyProton Magnetic Resonance SpectroscopyUrinalysisUrine

Identifiers

PMID39084612
PMCPMC11325295

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.