Evidence map›Paper›PMID 39083380›Full record

ArticleCell reports2024

MicroRNA-19b exacerbates systemic sclerosis through promoting Th9 cells.

Yun-Ji Lim, Sang-A Park, Dandan Wang, Wenwen Jin, Wai Lim Ku, Dunfang Zhang, Junji Xu, Liliana C Patiño, Na Liu, Weiwei Chen and 5 more

Erratum issuedAbstract read
In one paragraph

Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
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  6. Review
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Yun-Ji LimMucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, MD 20892, USA.
Sang-A ParkMucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, MD 20892, USA.
Dandan WangDepartment of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China.
Wenwen JinMucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, MD 20892, USA.
Wai Lim KuSystemic Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, 31 Center Drive, Bethesda, MD 20892, USA.
Dunfang ZhangMucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, MD 20892, USA.
Junji XuMucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, MD 20892, USA.
Liliana C PatiñoMucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, MD 20892, USA.
Na LiuMucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, MD 20892, USA.
Weiwei ChenDepartment of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China.
Rida KazmiMucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, MD 20892, USA.
Keji ZhaoSystemic Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, 31 Center Drive, Bethesda, MD 20892, USA.
Ying E ZhangLaboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892, USA.
Lingyun SunDepartment of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China. Electronic address: lingyunsun@nju.edu.cn.
WanJun ChenMucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, MD 20892, USA. Electronic address: wchen@nih.gov.

Funding

TGF-beta Regulation of Mucosal and Systemic T Cell Immunity and ToleranceZIADE000101 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI CHEN, WANJUN · 2009 to 2025
$36.9M
NIDCR DIR Scientific Cores (Combined Technical Research Core)ZICDE000729 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI ABSHARI, MEHRNOOSH · 2009 to 2025
$31.7M
Molecular Mechanisms of TGF-beta Signaling PathwayZIABC010419 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ZHANG, YING E · 2009 to 2025
$14.9M
Immunotherapy of inflammation, autoimmune disease and cancer ZIADE000737 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI CHEN, WANJUN · 2021 to 2025
$3.8M
Intramural NIH HHS Z99 DE999999Intramural NIH HHS ZIC DE000729
6 · The paper itself

Abstract

Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by fibrosis of the skin and multiple vital organs, but the immunological pathogenesis of SSc remains unclear. We show here that miR-19b promotes Th9 cells that exacerbate SSc. Specifically, miR-19b and interleukin (IL)-9 increase in CD4

Indexed as

Interleukin-9MicroRNAsScleroderma, SystemicAnimalsBleomycinFemaleHumansInterleukin-4MaleMAP Kinase Kinase Kinase 7MAP Kinase Kinase KinasesMiceMice, Inbred C57BLSignal TransductionSmad3 ProteinT-Lymphocytes, Helper-InducerBleomycinInterleukin-4Interleukin-9MAP Kinase Kinase Kinase 7MAP Kinase Kinase KinasesMicroRNAsMIRN19A microRNA, humanMIRN19 microRNA, mouseSmad3 ProteinTNF Receptor-Associated Factor 6Transforming Growth Factor betaCP: ImmunologyE2f8miR-19bNF-κB p65patients with systemic sclerosisTAK1TGF-β signalingTh9TRAF6

Identifiers

PMID39083380
PMCPMC11440512

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.