Evidence map›Paper›PMID 39083378›Full record

ArticleCell reports2024

SMYD5 is a regulator of the mild hypothermia response.

Salvor Rafnsdottir, Kijin Jang, Sara Tholl Halldorsdottir, Meghna Vinod, Arnhildur Tomasdottir, Katrin Möller, Katrin Halldorsdottir, Tinna Reynisdottir, Laufey Halla Atladottir, Kristin Elisabet Allison and 8 more

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In one paragraph

Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Salvor RafnsdottirLouma G. Laboratory of Epigenetic Research, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Kijin JangLouma G. Laboratory of Epigenetic Research, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Sara Tholl HalldorsdottirLouma G. Laboratory of Epigenetic Research, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Meghna VinodLouma G. Laboratory of Epigenetic Research, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Arnhildur TomasdottirLouma G. Laboratory of Epigenetic Research, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Katrin MöllerLouma G. Laboratory of Epigenetic Research, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Katrin HalldorsdottirLouma G. Laboratory of Epigenetic Research, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Tinna ReynisdottirLouma G. Laboratory of Epigenetic Research, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Laufey Halla AtladottirLouma G. Laboratory of Epigenetic Research, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Kristin Elisabet AllisonFaculty of Life and Environmental Sciences, University of Iceland, Reykjavik, Iceland.
Kevin OstacoloLouma G. Laboratory of Epigenetic Research, Faculty of Medicine, University of Iceland, Reykjavik, Iceland; Department of Genetics and Molecular Medicine, Landspitali University Hospital, Reykjavik, Iceland.
Jin HeDepartment of Biochemistry and Molecular Biology, College of Natural Science, Michigan State University, East Lansing, MI, USA.
Li ZhangMcKusick-Nathans Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Frances J NorthingtonDivision of Neonatology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Neuroscience Intensive Care Nursery Program, Johns Hopkins University, Baltimore, MD, USA.
Erna MagnusdottirDepartment of Biomedical Science and Department of Anatomy, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Raul Chavez-ValdezDivision of Neonatology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Neuroscience Intensive Care Nursery Program, Johns Hopkins University, Baltimore, MD, USA.
Kimberley Jade AndersonDepartment of Genetics and Molecular Medicine, Landspitali University Hospital, Reykjavik, Iceland.
Hans Tomas BjornssonLouma G. Laboratory of Epigenetic Research, Faculty of Medicine, University of Iceland, Reykjavik, Iceland; McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Pediatrics, Johns Hopkins University, Baltimore, MD, USA; Department of Genetics and Molecular Medicine, Landspitali University Hospital, Reykjavik, Iceland. Electronic address: htb@hi.is.

Funding

Imaging Neonatal Hypoxic Ischemic InjuryR01HD074593 · NICHD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FRANCES J NORTHINGTON, JIANGYANG ZHANG · 2013 to 2026
$6.8M
Elucidating factors affecting blood levels of tau and GFAP in adults at risk for neurodegenerationU01NS114144 · NINDS · MESO SCALE DIAGNOSTICS, LLC · PI STENGELIN, MARTIN · 2020 to 2024
$3.3M
Advanced therapeutic hypothermia efficacy network modeling in neonatal HIER01HD110091 · NICHD · JOHNS HOPKINS UNIVERSITY · PI EVERETT, ALLEN D, NORTHINGTON, FRANCES J · 2022 to 2025
$2.7M
Exploring Kabuki Syndrome as a Treatable Cause of Intellectual DisabilityDP5OD017877 · OD · JOHNS HOPKINS UNIVERSITY · PI BJORNSSON, HANS TOMAS · 2013 to 2017
$2.0M
Precision Medicine for Neonatal Hypoxic-Ischemic Encephalopathy: Combined Neuroimaging Clinical Approach to Link Phenotypes to PrognosisR01NS126549 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Kenichi Oishi · 2022 to 2026
$2.0M
Cholinergic neuron degeneration after HI: New target for delayed therapy of neonatal HI to improve Learning and Memory DeficitsR21NS123814 · NINDS · JOHNS HOPKINS UNIVERSITY · PI NORTHINGTON, FRANCES J · 2022 to 2023
$450k
NICHD NIH HHS R01 HD074593NICHD NIH HHS R01 HD110091NIH HHS DP5 OD017877NINDS NIH HHS R01 NS126549NINDS NIH HHS R21 NS123814NINDS NIH HHS U01 NS114144
6 · The paper itself

Abstract

The mild hypothermia response (MHR) maintains organismal homeostasis during cold exposure and is thought to be critical for the neuroprotection documented with therapeutic hypothermia. To date, little is known about the transcriptional regulation of the MHR. We utilize a forward CRISPR-Cas9 mutagenesis screen to identify the histone lysine methyltransferase SMYD5 as a regulator of the MHR. SMYD5 represses the key MHR gene SP1 at euthermia. This repression correlates with temperature-dependent levels of histone H3 lysine 26 trimethylation (H3K36me3) at the SP1 locus and globally, indicating that the mammalian MHR is regulated at the level of histone modifications. We have identified 37 additional SMYD5-regulated temperature-dependent genes, suggesting a broader MHR-related role for SMYD5. Our study provides an example of how histone modifications integrate environmental cues into the genetic circuitry of mammalian cells and provides insights that may yield therapeutic avenues for neuroprotection after catastrophic events.

Indexed as

Histone-Lysine N-MethyltransferaseHistonesAnimalsCRISPR-Cas SystemsGene Expression RegulationHEK293 CellsHumansHypothermiaMethylationMiceHistone-Lysine N-MethyltransferaseHistonescold stressCP: Metabolismepigeneticsgenetic environmental interactionH3K36me3histone machineryhistone methylationhypoxic brain injuryproteasomerepressorSP1

Identifiers

PMID39083378
PMCPMC11401508

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.