Evidence map›Paper›PMID 39083377›Full record

ArticleCell reports2024

Chronic viral infection alters PD-1 locus subnuclear localization in cytotoxic CD8

Catarina Sacristán, Ben A Youngblood, Peiyuan Lu, Alexander P R Bally, Jean Xiaojin Xu, Katelyn McGary, Susannah L Hewitt, Jeremy M Boss, Jane A Skok, Rafi Ahmed and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Catarina SacristánSkirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY, USA.
Ben A YoungbloodEmory Vaccine Center and the Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA; Immunology Department, St Jude Children's Research Hospital, Memphis, TN, USA.
Peiyuan LuEmory Vaccine Center and the Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA.
Alexander P R BallyEmory Vaccine Center and the Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA.
Jean Xiaojin XuEmory Vaccine Center and the Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA.
Katelyn McGarySkirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY, USA.
Susannah L HewittDepartment of Pathology, New York University School of Medicine, New York, NY, USA.
Jeremy M BossEmory Vaccine Center and the Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA.
Jane A SkokDepartment of Pathology, New York University School of Medicine, New York, NY, USA.
Rafi AhmedEmory Vaccine Center and the Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA.
Michael L DustinSkirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY, USA; The Kennedy Institute of Rheumatology, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. Electronic address: michael.dustin@kennedy.ox.ac.uk.

Funding

Targeting the PD-1 signaling pathway to rescue HIV T cell dysfunctionP01AI080192 · NIAID · EMORY UNIVERSITY · PI AHMED, RAFI · 2008 to 2012
$12.6M
Regulation of PD-1 gene expressionR01AI113021 · NIAID · EMORY UNIVERSITY · PI BOSS, JEREMY M. · 2014 to 2024
$4.7M
Requirement for Sensitive T Cell Response to AntigenR37AI043542 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DUSTIN, MICHAEL LORAN · 2007 to 2016
$3.6M
Inverted two photon laser scanning microscope for host defenseS10RR023704 · NCRR · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DUSTIN, MICHAEL LORAN · 2008 to 2008
$500k
NCRR NIH HHS S10 RR023704NIAID NIH HHS P01 AI080192NIAID NIH HHS R01 AI113021NIAID NIH HHS R37 AI043542Wellcome Trust
6 · The paper itself

Abstract

During chronic infection, virus-specific CD8

Indexed as

Lymphocytic ChoriomeningitisLymphocytic choriomeningitis virusMice, Inbred C57BLProgrammed Cell Death 1 ReceptorT-Lymphocytes, CytotoxicAnimalsCD8-Positive T-LymphocytesCell NucleusChronic DiseaseGenetic LociMicePositive Regulatory Domain I-Binding Factor 1Promoter Regions, GeneticPdcd1 protein, mousePositive Regulatory Domain I-Binding Factor 1Prdm1 protein, mouseProgrammed Cell Death 1 ReceptorBlimp-1CD8(+) T cellchronic viral infectionCP: ImmunologycytotoxicexhaustionL-selectinmethylationPD-1subnuclear localizationtranscription

Identifiers

PMID39083377
PMCPMC11522508

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.