Evidence map›Paper›PMID 39083220›Full record

Trial reportInternational journal of clinical pharmacy2024

Effectiveness and safety of remimazolam tosilate versus propofol for sedation in patients undergoing gastrointestinal endoscopy: a randomized controlled trial.

Dongbin Li, Yu Wang, Yang Xing, Zicen Zhao, Liya Chang, Yufang Leng

Abstract readRandomized Controlled TrialComparative Study
PubMed Publisher
In one paragraph

Trial report in International journal of clinical pharmacy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Trial
  4. Trial
  5. Trial
  6. Article
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  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dongbin LiThe First Clinical Medical College of Lanzhou University, Lanzhou, 730000, GanSu Province, China.ORCID http://orcid.org/0009-0003-3669-8869
Yu WangThe First Clinical Medical College of Lanzhou University, Lanzhou, 730000, GanSu Province, China.ORCID http://orcid.org/0009-0009-4141-2945
Yang XingThe First Clinical Medical College of Lanzhou University, Lanzhou, 730000, GanSu Province, China.ORCID http://orcid.org/0009-0000-8586-8375
Zicen ZhaoThe First Clinical Medical College of Lanzhou University, Lanzhou, 730000, GanSu Province, China.ORCID http://orcid.org/0009-0007-3500-5169
Liya ChangThe First Clinical Medical College of Lanzhou University, Lanzhou, 730000, GanSu Province, China.ORCID http://orcid.org/0009-0009-3735-9600
Yufang LengThe First Clinical Medical College of Lanzhou University, Lanzhou, 730000, GanSu Province, China. lengyf@lzu.edu.cn.ORCID http://orcid.org/0000-0001-7094-2413

Funding

Lanzhou University Medical Education Innovation and Development Program lzuyxcx-2022-108
6 · The paper itself

Abstract

backgroundRemimazolam tosilate is a new type of benzodiazepine currently used for gastrointestinal endoscopy and can be combined with alfentanil.

aimThis trial compared the effectiveness and safety of remimazolam with alfentanil to propofol with alfentanil in patients undergoing gastrointestinal endoscopy.

methodOne hundred and sixty-six patients were randomly divided into propofol-alfentanil anaesthesia (Group P) and remimazolam-alfentanil anaesthesia (Group R). The primary outcomes were perioperative haemodynamic variables, including systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR) and oxygen saturation (SpO

resultsCompared with those in Group P, the SBP in Group R was significantly higher at T1, T2, T3, and T6 (P < 0.05); the DBP and MAP were significantly higher at T1, T2, T3, T5, and T6 (P < 0.05); the HR was significantly faster at T1 to T6 (P < 0.05); the SpO

conclusionCompared to propofol with alfentanil, remimazolam with alfentanil can be used safely and effectively for sedation in patients undergoing gastrointestinal endoscopy, with less impact on the patient's circulatory and respiratory systems and a lower incidence of adverse events.

trial registrationThis trial protocol was registered in the Chinese Clinical Trial Registry (ChiCR2300077252, date: 2023-11-02).

Indexed as

AlfentanilBenzodiazepinesEndoscopy, GastrointestinalHypnotics and SedativesPropofolAdultAgedFemaleHumansMaleMiddle AgedPatient SatisfactionAlfentanilBenzodiazepinesHypnotics and SedativesPropofolremimazolamAlfentanilGastrointestinal endoscopyHypotensionPropofolRemimazolam

Identifiers

PMID39083220

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.