Evidence map›Paper›PMID 39083171›Full record

ArticleEndocrine2024

Mendelian randomization study of inflammatory bowel disease and type 1 diabetes.

Jing-Yi Zhu, Xinyi Ma, Mu-Yun Liu, Li-Zhe Ma, Xiao-Ru Sun, Mao-Yun Yan, Chunyu Xue, Chang Sun

Abstract read
PubMed Publisher
In one paragraph

Article in Endocrine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jing-Yi ZhuDepartment of Gastroenterology, First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China.
Xinyi MaDepartment of Plastic Surgery, Changhai Hospital, Naval Military Medical University, 168 Changhai Road, Shanghai, 200433, China.
Mu-Yun LiuDepartment of Gastroenterology, Navy No. 905 Hospital, Naval Medical University, Shanghai, 200433, China.
Li-Zhe MaDepartment of Gastroenterology, First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China.
Xiao-Ru SunDepartment of Gastroenterology, First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China.
Mao-Yun YanDepartment of Gastroenterology, First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China.
Chunyu XueDepartment of Plastic Surgery, Changhai Hospital, Naval Military Medical University, 168 Changhai Road, Shanghai, 200433, China. xuecyfun@163.com.
Chang SunDepartment of Gastroenterology, First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China. sunchang8211@163.com.ORCID 0000-0001-5660-0468

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOur purpose was to investigate and test the causal relationship between type 1 diabetes (T1D) and inflammatory bowel disease (IBD) and its major phenotypes, including ulcerative colitis (UC) and Crohn's disease (CD), in two large datasets.

methodsWe obtained IBD samples from the largest publicly available genome-wide association study (GWAS), as well as the FinnGen database and the publicly accessible IEU GWAS database of T1D. We employed a two-sample Mendelian randomization approach to assess bidirectional causality using the inverse variance weighting (IVW) method as the primary outcome.

resultsGenetic predisposition to T1D was associated with reduced risk of IBD (IVW: odds ratio (OR), 0.867; 95% confidence interval (CI), [0.852, 0.883]; P < 0.001), UC (OR = 0.879 [0.823, 0.939], P < 0.001), and CD (OR = 0.925 [0.872, 0.981], P = 0.009). The republication results found IBD genetically possessed negative association with T1D (OR = 0.781 [0.684, 0.891], P < 0.001). Additionally, a meta-analysis of results was conducted to prove the strong evidence between T1D and CD (OR = 0.95 [0.91, 0.98]; p = 0.01).

conclusionsThis study first demonstrated a causal effect of TID on the reduced risk of CD in the mendelian randomization study.

Indexed as

Diabetes Mellitus, Type 1Genetic Predisposition to DiseaseGenome-Wide Association StudyInflammatory Bowel DiseasesMendelian Randomization AnalysisColitis, UlcerativeCrohn DiseaseHumansPolymorphism, Single NucleotideCrohn’s diseaseTwo-sample Mendelian randomizationType 1 diabetesUlcerative colitis

Identifiers

PMID39083171

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.