Evidence map›Paper›PMID 39083105›Full record

ArticleEJNMMI research2024

Feasibility of safe outpatient treatment in pediatric patients following intraventricular radioimmunotherapy with

Kavya Prasad, Brian E Serencsits, Bae P Chu, Lawrence T Dauer, Maria Donzelli, Ellen Basu, Kim Kramer, Neeta Pandit-Taskar

Abstract read
In one paragraph

Article in EJNMMI research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The molecular blueprint of targeted radionuclide therapy.Nature reviews. Clinical oncology · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Kavya PrasadDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
Brian E SerencsitsDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
Bae P ChuDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
Lawrence T DauerDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
Maria DonzelliDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
Ellen BasuDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
Kim KramerDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
Neeta Pandit-TaskarMolecular Imaging and Therapy Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA. pandit-n@mskcc.org.ORCID http://orcid.org/0000-0003-1551-2036

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
INTRATHECAL 131 I 3F8 FOR LEPTOMENINGEAL MALIGNANCIESR21CA089935 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI KRAMER, KIM · 2000 to 2001
$749k
Treating CNS malignancies with 131-I-8H9R21CA117076 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI KRAMER, KIM · 2005 to 2006
$699k
INTRATHECAL RADIOIMMUNOTHERAPY OF CNS MALIGNANCIESK08CA072868 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI KRAMER, KIM · 1997 to 2001
$173k
Catie Hoch Foundation N/ALuke's Lollies N/ANCI NIH HHS P30 CA008748NCI NIH HHS R21 CA117076NIH HHS K08 CA072868NIH HHS R21 CA089935NIH HHS R21 CA117076Y-mAbs N/A
6 · The paper itself

Abstract

backgroundRadiolabeled antibody

methodsIntraventricular radioimmunotherapy (RIT) with 925-1850 MBq (25-50 mCi) of

resultsPost-administration exposure rates for patients ranged from 0.16 to 0.46 µSv/hr/MBq at 0.3 m and 0.03-0.08 µSv/hr/MBq at 1 m. Radiation exposure precautions ranged from 1 to 10 days after release for the four evaluated cohorts. Based on the highest measured exposure rates and slowest whole-body clearance, the longest precautions were approximately 78% lower than the regulatory guidance recommendations. Radiation exposure to staff associated with

conclusion

Indexed as

Brain metastasesRadiation safetyRadiopharmaceutical

Identifiers

PMID39083105
PMCPMC11291838

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.