ArticleEuropean journal of nuclear medicine and molecular imaging2024
Immunohistochemical ERG positivity is associated with decreased PSMA expression and lower visibility in corresponding [
Article in European journal of nuclear medicine and molecular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- The predictive role of [European journal of nuclear medicine and molecular imaging · 2026Article
- Dutasteride treatment and its effect on standardized uptake values in prostate-specific membrane antigen-PET imaging: A pilot study.PloS one · 2026Article
- LutetiumAdvances in radiation oncology · 2026Article
- Radiomics-based machine learning models for predicting genomic alterations in metastatic prostate cancer using PSMA PET imaging: a pilot study.EJNMMI reports · 2025Article
- Review
- The impact of short-term non-steroidal androgen antagonist therapy on PSMA expression and tumor cellularity studied with dynamic [EJNMMI research · 2025Article
- The role of PSMA-based radioligand therapy in hormone-sensitive prostate cancer.European journal of nuclear medicine and molecular imaging · 2025Review
- Exploring therapeutic applications ofFrontiers in oncology · 2025Review
Corrections and comments
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Authors and funding
11 authors.
Funding
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Abstract
purposeTMPRSS2:ERG gene fusion negatively regulates PSMA expression in prostate adenocarcinoma (PCa) cell lines. Therefore, immunohistochemical (IHC) ERG expression, a surrogate for an underlying ERG rearrangement, and PSMA expression patterns in radical prostatectomy (RPE) specimens of primary PCa, including corresponding PSMA-PET scans were investigated.
methodsTwo cohorts of RPE samples (total n=148): In cohort #1 (n=62 patients) with available RPE and preoperative [
resultsCohort #1: PCa with IHC-ERG expression (35.5%) showed significantly lower IHC-PSMA expression and lower SUV
conclusionIHC-ERG expression is significantly associated with more heterogeneous and lower IHC-PSMA tissue expression in two independent RPE cohorts. There is a strong association of ERG positivity in RPE tissue with lower [
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