Evidence map›Paper›PMID 39082827›Full record

ArticleMicrobiology spectrum2024

Exploring synergistic and antagonistic interactions in phage-antibiotic combinations against ESKAPE pathogens.

Ashlan J Kunz Coyne, Mirna Eshaya, Callan Bleick, Samantha Vader, Biswajit Biswas, Melanie Wilson, Michael V Deschenes, Jose Alexander, Susan M Lehman, Michael J Rybak

Abstract read
In one paragraph

Article in Microbiology spectrum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Impact ofAntimicrobial agents and chemotherapy · 2026
    Article
  12. Integrated bioassays and metabolomics identifyFrontiers in microbiology · 2026
    Article
  13. Phage therapy againstFrontiers in microbiology · 2026
    Review
  14. Article
  15. Article
  16. Review
  17. Eravacycline: evaluation of susceptibility testing methods and activity against multidrug-resistant Enterobacterales and Acinetobacter.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ashlan J Kunz CoyneAnti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA.ORCID 0000-0002-4891-8625
Mirna EshayaAnti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA.
Callan BleickAnti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA.ORCID 0009-0004-6232-6804
Samantha VaderAnti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA.
Biswajit BiswasNaval Medical Research Center-Fort Detrick, Frederick, Maryland, USA.
Melanie WilsonNaval Medical Research Center-Fort Detrick, Frederick, Maryland, USA.
Michael V DeschenesNaval Medical Research Center-Fort Detrick, Frederick, Maryland, USA.
Jose AlexanderDepartment of Microbiology, Virology and Immunology, AdventHealth Central Florida, Orlando, Florida, USA.
Susan M LehmanCenter for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.ORCID 0000-0002-5831-8148
Michael J RybakAnti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA.ORCID 0000-0003-2220-0081

Funding

Anti-biofilm activity of bacteriophage-antibiotic combinations against MRSAR21AI163726 · NIAID · WAYNE STATE UNIVERSITY · PI RYBAK, MICHAEL JOSEPH · 2021 to 2022
$424k
NIAID NIH HHS R21 AI163726
6 · The paper itself

Abstract

In the era of antimicrobial resistance, phage-antibiotic combinations offer a promising therapeutic option, yet research on their synergy and antagonism is limited. This study aims to assess these interactions, focusing on protein synthesis inhibitors and cell envelope-active agents against multidrug-resistant bacterial strains. We evaluated synergistic and antagonistic interactions in multidrug-resistant

Indexed as

Anti-Bacterial AgentsEnterococcus faeciumMicrobial Sensitivity TestsPseudomonas aeruginosaAzithromycinBacteriophagesCefepimeCeftarolineDaptomycinDrug Resistance, Multiple, BacterialGentamicinsHumansLinezolidPhage TherapyProtein Synthesis InhibitorsStaphylococcus aureusAnti-Bacterial AgentsAzithromycinCefepimeCeftarolineDaptomycinGentamicinsLinezolidProtein Synthesis InhibitorsantagonismantibioticbacteriophageEnterococcus faeciumPseudomonas aeruginosaStaphylococcus aureus

Identifiers

PMID39082827
PMCPMC11468199

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.