Evidence map›Paper›PMID 39082775›Full record

ArticleThe Journal of frailty & aging2024

Body Composition, Falls, and Freezing of Gait in Parkinson's Disease: Gender-Specific Effects.

C Pongmala, C Stonsaovapak, M van Emde Boas, H Bhanderi, A Luker, F Michalakis, P Kanel, R L Albin, J M Haus, N I Bohnen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of frailty & aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

C PongmalaChatkaew Pongmala, Ph.D., Functional Neuroimaging, Cognitive and Mobility Laboratory, Department of Radiology, University of Michigan, 24 Frank Lloyd Wright Drive, Box 362, Ann Arbor, MI 48105-9755, USA. TEL: (1) 734 998 8400. E-mail: pchatkae@umich.edu.
C Stonsaovapak
M van Emde Boas
H Bhanderi
A Luker
F Michalakis
P Kanel
R L Albin
J M Haus
N I Bohnen

Funding

Study in Parkinson Disease of Exercise Phase 3 Clinical Trial: SPARX3U01NS113851 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniel M. Corcos · 2019 to 2026
$29.6M
Udall Catalyst Research Project: Retrosplenial Cholinergic and Attentional-Motor Integration DysfunctionP50NS123067 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI AHMED, OMAR JAMIL · 2021 to 2025
$11.6M
Michigan Alzheimer's Disease Core CenterP30AG053760 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DODGE, HIROKO HAYAMA · 2016 to 2020
$10.1M
Public Outreach and Education CoreP50NS091856 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAUER, WILLIAM T. · 2014 to 2019
$10.1M
Treating mild cognitive impairment with transcranial direct current stimulationR01AG058724 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAMPSTEAD, BENJAMIN MICHAEL · 2018 to 2022
$8.4M
The Study of the Environment and Alzheimer's disease and related Dementias (SEAD)R01AG070897 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BAKULSKI, KELLY, PARK, SUNG KYUN · 2021 to 2025
$3.4M
Strategies and Functional Outcomes of Enhancing in Vivo Production of Soluble Rage IsoformsR01DK109948 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAUS, JACOB M · 2016 to 2020
$3.1M
Central cholinergic presbyvestibulopathy network changes and imbalance in Parkinson's disease and older personsR01AG073100 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOHNEN, NICOLAAS IDA · 2021 to 2025
$3.0M
Hyposmia, Cholinergic Denervation and Incipient Cognitive Decline in PDR01NS070856 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOHNEN, NICOLAAS IDA · 2010 to 2014
$1.9M
NeuroNEXT Clinical Research Site at the University of MichiganU24NS107158 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHOU, KELVIN L · 2018 to 2022
$1.6M
UM Clinical Neuroscientist Training ProgramR25NS089450 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALBIN, ROGER L · 2014 to 2023
$1.3M
Exploring regulatory mechanisms of glyoxalase-1R21AG081916 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAUS, JACOB M · 2023 to 2024
$429k
NIA NIH HHS P30 AG053760NIA NIH HHS R01 AG058724NIA NIH HHS R01 AG070897NIA NIH HHS R01 AG073100NIA NIH HHS R21 AG081916NIDDK NIH HHS R01 DK109948NINDS NIH HHS P50 NS091856NINDS NIH HHS P50 NS123067NINDS NIH HHS R01 NS070856NINDS NIH HHS R21 NS114749NINDS NIH HHS R25 NS089450NINDS NIH HHS U01 NS113851NINDS NIH HHS U24 NS107158RRD VA I01 RX001631
6 · The paper itself

Abstract

backgroundPostural instability and gait difficulties (PIGD) are a significant cause of mobility loss and lower quality of life in Parkinson's disease (PD). When PD progresses, patients may experience falls and freezing of gait (FoG) resulting in fear of falling and increasing sedentariness. Sedentary behavior results in sarcopenia associated with other changes in body composition, especially in older patients becoming frail. Previous studies have shown gender-specific changes in body composition with aging as well as gender disparities in symptoms and progression of PD, yet the association between gender-specific body composition and PIGD symptoms such as FoG along with falls, remains unexplored. OBECTIVE: This study aimed to investigate the association between gender-specific changes in body composition, FoG and falls assessment.

methods136 PD subjects underwent detailed clinical test batteries and had whole-body composition assessed using dual-energy X-ray absorptiometry (DXA). Multivariate logistic forward stepwise regression was performed to define body composition associations for FoG and falls.

resultsMultivariate regression analysis revealed that in males with PD, lower leg lean mass was significantly associated with the presence of FoG (OR, 0.429; 95% CI, 0.219-0.839; p=0.013) but not with falls. In females with PD, higher leg adipose mass was significantly associated with falls (OR, 4.780; 95% CI, 1.506-15.174; p=0.008) but not with FoG.

conclusionThese observations suggest gender specific associations between body composition and FoG vs. falls in PD. Future research should explore the impact of interventions on body composition in individuals with PD by paying specific attention to gender differences.

Indexed as

Accidental FallsBody CompositionGait Disorders, NeurologicParkinson DiseaseAbsorptiometry, PhotonAgedAged, 80 and overFemaleHumansMaleMiddle AgedPostural BalanceSex FactorsALMIFat massgender differencesmuscle weaknessrisk factors

Identifiers

PMID39082775
PMCPMC11292035

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.