Evidence map›Paper›PMID 39082202›Full record

ArticleHistology and histopathology2025

SIRT4 is associated with microvascular infiltration, immune cell infiltration, and epithelial mesenchymal transition in hepatocellular carcinoma.

Juan Li, Ming Zhao, Weiwei Fan, Na Na, Hui Chen, Ming Liang, Sheng Tai, Shan Yu

Abstract read
PubMed Publisher
In one paragraph

Article in Histology and histopathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Juan LiDepartment of Pathology, The Second Affiliated Hospital of Harbin Medical University, Harbin, PR China.
Ming ZhaoDepartment of Gastroenterology, Clinical Medical College and the First Affiliated Hospital of Chengdu Medical College, Sichuan, PR China.
Weiwei FanDepartment of Infectious Diseases, The Second Affiliated Hospital of Harbin Medical University, Harbin, PR China.
Na NaDepartment of Pathology, The Second Affiliated Hospital of Harbin Medical University, Harbin, PR China.
Hui ChenDepartment of Finance, Harbin Finance University, Harbin, PR China.
Ming LiangDepartment of Infectious Diseases, The Second Affiliated Hospital of Harbin Medical University, Harbin, PR China.
Sheng TaiDepartment of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, PR China.
Shan YuDepartment of Pathology, The Second Affiliated Hospital of Harbin Medical University, Harbin, PR China. yushan@hrbmu.edu.cn.

Funding

National Natural Science Foundation of China 81972724
6 · The paper itself

Abstract

aimsHepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide. In the present study, we evaluated SIRT4 expression levels in HCC specimens and investigated the relationships between SIRT4 expression levels, clinicopathological factors, and microvascular infiltration (MVI) in HCC.

methodsThe expression levels of SIRT4 in 108 HCC specimens were examined by immunohistochemical staining. MVI in HCC specimens was divided into three subtypes: M0, M1, and M2. Comprehensive bioinformatics analysis was carried out to demonstrate SIRT4's biological functions and expression-related prognostic value.

resultsThe diffuse cytoplasmic expression pattern of SIRT4 was observed in all adjacent nonneoplastic liver tissues. The levels of SIRT4 were higher in HCC than in any other type of cancer and normal tissues. In addition, the expression levels of SIRT4 were significantly decreased in HCC tissues when MVI was M1 or M2 (

conclusionsOur results demonstrated an association between SIRT4 expression levels, MVI, immune cell infiltration, and potential biological functions, including EMT in the progression of HCC.

Indexed as

Carcinoma, HepatocellularEpithelial-Mesenchymal TransitionLiver NeoplasmsSirtuinsAdultAgedBiomarkers, TumorFemaleHumansMaleMicrovesselsMiddle AgedMitochondrial ProteinsPrognosisBiomarkers, TumorMitochondrial ProteinsSIRT4 protein, humanSirtuins

Identifiers

PMID39082202

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.