ArticleSmall (Weinheim an der Bergstrasse, Germany)2024
Hydrodynamics and Aggregation of Nanoparticles with Protein Corona: Effects of Protein Concentration and Ionic Strength.
Article in Small (Weinheim an der Bergstrasse, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed.
- Patient-Derived Organoids as a Model to Understand Tumor Microenvironment-Driven Nano-Bio Interactions - A Framework Towards Improved Nanomedicine Translation.bioRxiv : the preprint server for biology · 2026Article
- Adenosine and guanosine-based oligonucleotides-loaded PLGA nanoparticles attenuates progression of surgically induced osteoarthritis.Drug delivery and translational research · 2026Article
- Tuning protein corona on nucleic acid nanodrugs for targeted delivery.Acta pharmaceutica Sinica. B · 2026Review
- Lysosomal aggregation of iron nanoparticles guided by multistage transformation induces potent ferroptosis.Materials today. Bio · 2026Article
- The Effect of CuACS chemical neuroscience · 2026Article
- Effects of Liposome Composition and Size on Protein Corona Formation: Competitive Replacement of Abundant Proteins by High-Affinity Proteins on the Liposome Surface.Advanced healthcare materials · 2026Article
- Effect of Wall-Material Assembly Sequence on Ovalbumin-Chitosan Nanoparticles for Antarctic Krill Peptide Delivery.Foods (Basel, Switzerland) · 2026Article
- The Development and Optimisation of a Spinosin Solid-Dispersion-Based Functional Dairy Beverage and Its Sleep-Promoting Effects in Mice.Foods (Basel, Switzerland) · 2026Article
- Exploring the Potential Role of Manganese-Based Zeolitic Imidazolate Framework Nanoparticles in Cancer Therapy:International journal of nanomedicine · 2026Article
- Inactivated Enterovirus 71 Particle Aggregation Stability: Dynamic Light Scattering Analysis and Stabilizer Identification.Vaccines · 2025Article
- Albumin-Coated Copper Oxide Nanoparticles for Radiosensitization of Human Glioblastoma Cells Under Clinically Relevant X-Ray Irradiation.Nanomaterials (Basel, Switzerland) · 2025Article
- Innovative Controlled-Release Systems for Fucoxanthin: Research Progress and Applications.Pharmaceutics · 2025Review
- The Protein Corona Paradox: Challenges in Achieving True Biomimetics in Nanomedicines.Biomimetics (Basel, Switzerland) · 2025Review
- Formation Mechanisms of Protein Coronas on Food-Related Nanoparticles: Their Impact on Digestive System and Bioactive Compound Delivery.Foods (Basel, Switzerland) · 2025Review
- Characteristics of exopolysaccharides - egg white protein composite gel and its application in low - fat sausage.Food chemistry: X · 2025Article
- Hydrodynamics and Aggregation of Nanoparticles with Protein Corona: Effects of Protein Concentration and Ionic Strength.Small (Weinheim an der Bergstrasse, Germany) · 2024Article
- Recent Advances in Simulation Studies on the Protein Corona.Pharmaceutics · 2024Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple 10 nm-sized anionic nanoparticles complexed with plasma proteins (human serum albumin (SA) or immunoglobulin gamma-1 (IgG)) at different ratios are simulated using all-atom and coarse-grained models. Coarse-grained simulations show much larger hydrodynamic radii of individual particles at a low protein concentration (a protein-to-particle ratio of 1) than at high protein concentrations or without proteins, indicating particle aggregation only at such a low protein concentration, in agreement with experiments. This particle aggregation is attributed to both electrostatic and hydrophobic particle-protein interactions, to an extent dependent on different proteins. In all-atom simulations, IgG proteins induce particle aggregation with and without salt, while SA proteins promote particle aggregation only in the presence of salt that can weaken the electrostatic repulsion between anionic particles closely linked via SA that is smaller than IgG, which also agree well with experiments. Besides charge interactions, hydrophobic interactions between particles and proteins are also important especially at the high salt concentration, leading to the increased particle-protein contact area. These findings help explain experimental observations regarding that the effects of protein concentration and ionic strength on particle aggregation depend on different plasma proteins, which are interpreted by binding free energies, electrostatic, and hydrophobic interactions between particles and proteins.
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Registered trials
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