Evidence map›Paper›PMID 39082000›Full record

ArticleFrontiers in dementia2023

Neuromelanin-sensitive MRI correlates of cognitive and motor function in Parkinson's disease with freezing of gait.

Daniel E Huddleston, Xiangchuan Chen, Kristy Hwang, Jason Langley, Richa Tripathi, Kelsey Tucker, J Lucas McKay, Xiaoping Hu, Stewart A Factor

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in dementia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Implications and opportunities regarding biological frameworks in overt and prodromal dementia with Lewy bodies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  3. Neuromelanin-sensitive MRI for mechanistic research and biomarker development in psychiatry.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Daniel E HuddlestonJean and Paul Amos Parkinson's Disease and Movement Disorder Program, Department of Neurology, Emory University, Atlanta, GA, United States.
Xiangchuan ChenJean and Paul Amos Parkinson's Disease and Movement Disorder Program, Department of Neurology, Emory University, Atlanta, GA, United States.
Kristy HwangDepartment of Neurology, University of California, San Diego, La Jolla, CA, United States.
Jason LangleyCenter for Advanced Neuroimaging, University of California, Riverside, Riverside, CA, United States.
Richa TripathiJean and Paul Amos Parkinson's Disease and Movement Disorder Program, Department of Neurology, Emory University, Atlanta, GA, United States.
Kelsey TuckerJean and Paul Amos Parkinson's Disease and Movement Disorder Program, Department of Neurology, Emory University, Atlanta, GA, United States.
J Lucas McKayJean and Paul Amos Parkinson's Disease and Movement Disorder Program, Department of Neurology, Emory University, Atlanta, GA, United States.
Xiaoping HuCenter for Advanced Neuroimaging, University of California, Riverside, Riverside, CA, United States.
Stewart A FactorJean and Paul Amos Parkinson's Disease and Movement Disorder Program, Department of Neurology, Emory University, Atlanta, GA, United States.

Funding

MRI Signatures of Neuromelanin and Iron Pathology in ParkinsonismK23NS105944 · NINDS · EMORY UNIVERSITY · PI HUDDLESTON, DANIEL · 2018 to 2022
$963k
NINDS NIH HHS K23 NS105944
6 · The paper itself

Abstract

Substantia nigra pars compacta (SNc) and locus coeruleus (LC) are neuromelanin-rich nuclei implicated in diverse cognitive and motor processes in normal brain function and disease. However, their roles in aging and neurodegenerative disease mechanisms have remained unclear due to a lack of tools to study them

Indexed as

agingcognitioncognitive reservefreezing of gait (FOG)neuromelanin (NM)neuromelanin-sensitive MRI (NM-MRI)Parkinson's disease (PD)substantia nigra (SN)

Identifiers

PMID39082000
PMCPMC11285586

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.