Evidence map›Paper›PMID 39081989›Full record

ArticleFrontiers in dementia2023

Differences in pharmacologic and demographic factors in male and female patients with vascular dementia, Alzheimer's disease, and mixed vascular dementia.

Madison Stanley, Nicolas Poupore, Krista Knisely, Alyssa Miller, Adebobola Imeh-Nathaniel, Laurie Theriot Roley, Samuel Imeh-Nathaniel, Rich Goodwin, Thomas I Nathaniel

Abstract read
In one paragraph

Article in Frontiers in dementia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Madison StanleySchool of Medicine Greenville, University of South Carolina, Greenville, SC, United States.
Nicolas PouporeSchool of Medicine Greenville, University of South Carolina, Greenville, SC, United States.
Krista KniselySchool of Medicine Greenville, University of South Carolina, Greenville, SC, United States.
Alyssa MillerDepartment of Biology, North Greenville University, Tigerville, SC, United States.
Adebobola Imeh-NathanielDepartment of Biology, North Greenville University, Tigerville, SC, United States.
Laurie Theriot RoleyPrisma Health, Greer, SC, United States.
Samuel Imeh-NathanielDepartment of Biology, North Greenville University, Tigerville, SC, United States.
Rich GoodwinSchool of Medicine Greenville, University of South Carolina, Greenville, SC, United States.
Thomas I NathanielSchool of Medicine Greenville, University of South Carolina, Greenville, SC, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Increasing evidence suggests that demographic and pharmacologic factors may play a significant role in the epidemiology of dementia. Sex differences in prevalence also depend on dementia subtypes, such as Alzheimer's dementia (AD), vascular dementia (VaD), and mixed vascular-Alzheimer's dementia (MVAD). Therefore, studies are needed to investigate sex-specific differences, and identify potential therapeutic targets for both sexes. Methods: Data was collected from the Prisma Health-Upstate Alzheimer's registry from 2016 to 2021 for 6,039 VaD patients, 9,290 AD patients, and 412 MVAD patients. A logistic regression was used to determine demographic and pharmacological factors associated with gender differences in patients with VaD, AD, and MVAD. Results: In patients with VaD, African Americans (OR = 1.454, 95% CI, 1.257-1.682, Conclusions: Our study revealed gender differences and similarities in the demographic and pharmacological factors of VaD, AD, and MVAD. Prospective studies are needed to determine the role of demographic and pharmacological factors in reducing sex-based disparities among VaD, AD, and MVAD patients.

Indexed as

Alzheimer's diseasedementiamale and femalemixed vascular dementiavascular dementia (VaD)

Identifiers

PMID39081989
PMCPMC11285705

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.