Evidence map›Paper›PMID 39081834›Full record

ArticleCanadian journal of gastroenterology & hepatology2024

Long-Term Treatment with Bulevirtide in Patients with Chronic Hepatitis D and Advanced Chronic Liver Disease.

Ayaz Sapuk, Leonie Steinhoff, Kristin Huenninghaus, Katharina Willuweit, Jassin Rashidi Alavijeh, Benedikt Hild, Lucia Asar, Hartmut H Schmidt, Christoph Schramm

Abstract read
In one paragraph

Article in Canadian journal of gastroenterology & hepatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Impact of Handling Perception and Language Barriers on Virologic Response to Daily Subcutaneous Bulevirtide in Hepatitis D.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Article
  5. Observational
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ayaz SapukDepartment of Gastroenterology, Hepatology and Transplantational Medicine University Hospital Essen, and Faculty of Medicine University of Duisburg-Essen, Essen, Germany.
Leonie SteinhoffDepartment of Gastroenterology, Hepatology and Transplantational Medicine University Hospital Essen, and Faculty of Medicine University of Duisburg-Essen, Essen, Germany.
Kristin HuenninghausDepartment of Gastroenterology, Hepatology and Transplantational Medicine University Hospital Essen, and Faculty of Medicine University of Duisburg-Essen, Essen, Germany.
Katharina WilluweitDepartment of Gastroenterology, Hepatology and Transplantational Medicine University Hospital Essen, and Faculty of Medicine University of Duisburg-Essen, Essen, Germany.
Jassin Rashidi AlavijehDepartment of Gastroenterology, Hepatology and Transplantational Medicine University Hospital Essen, and Faculty of Medicine University of Duisburg-Essen, Essen, Germany.
Benedikt HildDepartment of Gastroenterology, Hepatology and Transplantational Medicine University Hospital Essen, and Faculty of Medicine University of Duisburg-Essen, Essen, Germany.
Lucia AsarInstitute for Virology University Hospital Essen, and Faculty of Medicine University of Duisburg-Essen, Essen, Germany.
Hartmut H SchmidtDepartment of Gastroenterology, Hepatology and Transplantational Medicine University Hospital Essen, and Faculty of Medicine University of Duisburg-Essen, Essen, Germany.
Christoph SchrammDepartment of Gastroenterology, Hepatology and Transplantational Medicine University Hospital Essen, and Faculty of Medicine University of Duisburg-Essen, Essen, Germany.ORCID 0000-0001-6752-0690

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bulevirtide (BLV) is approved for the treatment of chronic hepatitis D (CHD). Because only limited long-term experience has been reported, we aimed to evaluate the efficacy and safety of BLV treatment in patients with advanced chronic liver disease (ACLD). We performed a retrospective analysis of patients with CHD who received BLV 2 mg/day for >12 months at a tertiary center. Virological response (VR) was defined as a reduction in hepatitis delta virus-ribonucleic acid (HDV-RNA) ≥2 log

Indexed as

Antiviral AgentsHepatitis D, ChronicHepatitis Delta VirusAdultFemaleHumansLiver CirrhosisMaleMiddle AgedPeptide FragmentsRetrospective StudiesRNA, ViralTreatment OutcomeAntiviral AgentsPeptide FragmentsRNA, Viral

Identifiers

PMID39081834
PMCPMC11288691

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.