Evidence map›Paper›PMID 39081810›Full record

ArticlePlastic and reconstructive surgery. Global open2024

Effect of ASC Injection in the Inflammatory Reaction in Silicone Implant Capsule: Animal Model.

Cristina Pires Camargo, Deborah Luisa de Sousa Santos, Viviane Abreu Nunes Cerqueira Dantas, Tatiane Katsue Furuya, Bruna Leticia Freitas-Marchi, Maria José Ferreira Alves, Miyuki Uno, Rolf Gemperli

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Article in Plastic and reconstructive surgery. Global open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cristina Pires CamargoFrom the Microsurgery and Plastic Surgery Laboratory, School of Medicine, Universidade de São Paulo, São Paulo, SP, Brazil.
Deborah Luisa de Sousa SantosMultiprofessional Residency Program in Oncology Care for Adults, Comissão de Residência Multiprofissional (COREMU), Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, SP, Brazil.
Viviane Abreu Nunes Cerqueira DantasLaboratório de Fisiologia da Pele e Bioengenharia Tecidual, Escola de Artes, Ciências e Humanidades (EACH-USP), São Paulo, SP, Brazil.
Tatiane Katsue FuruyaCenter for Translational Research in Oncology (LIM24), Instituto do Cancer do Estado de Sao Paulo (ICESP), Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP), Sao Paulo, SP, Brazil.
Bruna Leticia Freitas-MarchiLaboratório de Fisiologia da Pele e Bioengenharia Tecidual, Escola de Artes, Ciências e Humanidades (EACH-USP), São Paulo, SP, Brazil.
Maria José Ferreira AlvesCenter for Translational Research in Oncology (LIM24), Instituto do Cancer do Estado de Sao Paulo (ICESP), Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP), Sao Paulo, SP, Brazil.
Miyuki UnoCenter for Translational Research in Oncology (LIM24), Instituto do Cancer do Estado de Sao Paulo (ICESP), Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP), Sao Paulo, SP, Brazil.
Rolf GemperliPlastic Surgery Division, School of Medicine, Universida de São Paulo, São Paulo, SP, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Capsular contracture is a common complication affecting about 80% of patients who receive radiotherapy after breast reconstruction with silicone prostheses. This study examines the use of adipocyte stem cells (ASCs) to treat capsular contracture. Methods: Thirty rats were operated on to implant a minisilicone prosthesis in the dorsal region. The rats were divided into three groups: control (saline solution injection), radiotherapy (RDT), and RDT + ASC. After 3 months, the capsules were collected and submitted to histological analysis for inflammatory cell presence, vascular density, and collagen fibers, and gene expression of Tnf, Results: In macroscopic analysis, the RTGO score showed a two-point reduction in RDT + ASC compared with the RDT ( Conclusion: This study suggests that ASC treatment decreases silicone prosthesis capsule inflammation.

Identifiers

PMID39081810
PMCPMC11288612

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.