Evidence map›Paper›PMID 39081666›Full record

ReviewFrontiers in cellular neuroscience2024

Glial cells in the mammalian olfactory bulb.

Dan Zhao, Meigeng Hu, Shaolin Liu

Abstract readReview
In one paragraph

Review in Frontiers in cellular neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Glial pathology networks reveal early olfactory vulnerability in post mortem human Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Dan Zhao *Isakson Center for Neurological Disease Research, Department of Physiology and Pharmacology, Department of Biomedical Sciences, University of Georgia College of Veterinary Medicine, Athens, GA, United States.
Meigeng Hu *Isakson Center for Neurological Disease Research, Department of Physiology and Pharmacology, Department of Biomedical Sciences, University of Georgia College of Veterinary Medicine, Athens, GA, United States.
Shaolin LiuIsakson Center for Neurological Disease Research, Department of Physiology and Pharmacology, Department of Biomedical Sciences, University of Georgia College of Veterinary Medicine, Athens, GA, United States.

Funding

The inflammatory mechanisms underlying olfactory dysfunction in prognosis of TBI progression to dementiaR01AG077541 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI Shaolin Liu, Junfang Wu · 2022 to 2026
$3.1M
Cellular and circuit mechanisms underlying APOE-4 effects on olfaction.RF1AG069196 · NIA · UNIVERSITY OF GEORGIA · PI LIU, SHAOLIN · 2020 to 2020
$1.8M
APOE4 effects on glia-neuron interaction in the olfactory bulbR01AG074216 · NIA · UNIVERSITY OF GEORGIA · PI Shaolin Liu · 2022 to 2026
$1.8M
Mechanisms underlying APOE-4 effects on olfactory bulb circuitsR01DC014447 · NIDCD · UNIVERSITY OF MARYLAND BALTIMORE · PI LIU, SHAOLIN · 2016 to 2020
$1.6M
Cellular and circuit mechanisms underlying APOE-4 effects on olfaction.R01AG069196 · NIA · UNIVERSITY OF GEORGIA · PI LIU, SHAOLIN · 2024 to 2024
$1.1M
NIA NIH HHS R01 AG069196NIA NIH HHS R01 AG074216NIA NIH HHS R01 AG077541NIA NIH HHS RF1 AG069196NIDCD NIH HHS R01 DC014447
6 · The paper itself

Abstract

The mammalian olfactory bulb (OB), an essential part of the olfactory system, plays a critical role in odor detection and neural processing. Historically, research has predominantly focused on the neuronal components of the OB, often overlooking the vital contributions of glial cells. Recent advancements, however, underscore the significant roles that glial cells play within this intricate neural structure. This review discus the diverse functions and dynamics of glial cells in the mammalian OB, mainly focused on astrocytes, microglia, oligodendrocytes, olfactory ensheathing cells, and radial glia cells. Each type of glial contributes uniquely to the OB's functionality, influencing everything from synaptic modulation and neuronal survival to immune defense and axonal guidance. The review features their roles in maintaining neural health, their involvement in neurodegenerative diseases, and their potential in therapeutic applications for neuroregeneration. By providing a comprehensive overview of glial cell types, their mechanisms, and interactions within the OB, this article aims to enhance our understanding of the olfactory system's complexity and the pivotal roles glial cells play in both health and disease.

Indexed as

functionglial cellsinteractionneurodegenerationolfactory bulb

Identifiers

PMID39081666
PMCPMC11286597

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.