Evidence map›Paper›PMID 39081460›Full record

ArticleTrauma surgery & acute care open2024

Prior traumatic brain injury is a risk factor for in-hospital mortality in moderate to severe traumatic brain injury: a TRACK-TBI cohort study.

John K Yue, Leila L Etemad, Mahmoud M Elguindy, Thomas A van Essen, Patrick J Belton, Lindsay D Nelson, Michael A McCrea, Rick J G Vreeburg, Christine J Gotthardt, Joye X Tracey and 48 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Trauma surgery & acute care open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02119182 (Transforming Research and Clinical Knowledge in Traumatic Brain Injury), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02119182 completednot on this map

Transforming Research and Clinical Knowledge in Traumatic Brain Injury

TypeobservationalSponsorUniversity of California, San FranciscoRan2014 to 2020Enrolled2,996ConditionsTraumatic Brain InjuryArmsIn-Person Outcome Assessment, Phone Outcome Assessment, 3T Magnetic Resonance Imaging (MRI), Blood Draw for Plasma, DNA, Serum, RNA
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  5. Observational
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

58 authors.

John K YueNeurological Surgery, University of California San Francisco, San Francisco, California, USA.ORCID 0000-0001-9694-7722
Leila L EtemadNeurological Surgery, University of California San Francisco, San Francisco, California, USA.
Mahmoud M ElguindyNeurological Surgery, University of California San Francisco, San Francisco, California, USA.
Thomas A van EssenNeurological Surgery, Leiden University Medical Center, Leiden, Netherlands.
Patrick J BeltonNeurological Surgery, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Lindsay D NelsonNeurology and Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Michael A McCreaNeurology and Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Rick J G VreeburgNeurological Surgery, Leiden University Medical Center, Leiden, Netherlands.
Christine J GotthardtNeurological Surgery, University of California San Francisco, San Francisco, California, USA.
Joye X TraceyNeurological Surgery, University of California San Francisco, San Francisco, California, USA.
Bukre C CoskunNeurological Surgery, University of California San Francisco, San Francisco, California, USA.
Nishanth KrishnanNeurological Surgery, University of California San Francisco, San Francisco, California, USA.
Cathra HalabiNeurology, University of California San Francisco, San Francisco, California, USA.
Shawn R EagleNeurological Surgery, University of Pittsburgh Medical Center Health System, Pittsburgh, Pennsylvania, USA.
Frederick K KorleyEmergency Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Claudia S RobertsonNeurological Surgery, Baylor College of Medicine, Houston, Texas, USA.
Ann-Christine DuhaimeNeurological Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.
Gabriela G SatrisNeurological Surgery, University of California San Francisco, San Francisco, California, USA.
Phiroz E TaraporeNeurological Surgery, University of California San Francisco, San Francisco, California, USA.
Michael C HuangNeurological Surgery, University of California San Francisco, San Francisco, California, USA.
Debbie Y MadhokEmergency Medicine, University of California San Francisco, San Francisco, California, USA.
Joseph T GiacinoPhysical Medicine and Rehabilitation, Massachusetts General Hospital, Boston, Massachusetts, USA.
Pratik MukherjeeRadiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.
Esther L YuhRadiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.
Alex B ValadkaNeurological Surgery, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Ava M PuccioNeurological Surgery, University of Pittsburgh Medical Center Health System, Pittsburgh, Pennsylvania, USA.
David O OkonkwoNeurological Surgery, University of Pittsburgh Medical Center Health System, Pittsburgh, Pennsylvania, USA.
Xiaoying SunBiostatistics Research Center, Herbert Wertheim School of Public Health and Longevity Science, University of California San Diego, La Jolla, California, USA.
Sonia JainBiostatistics Research Center, Herbert Wertheim School of Public Health and Longevity Science, University of California San Diego, La Jolla, California, USA.
Geoffrey T ManleyNeurological Surgery, University of California San Francisco, San Francisco, California, USA.
Anthony M DiGiorgioNeurological Surgery, University of California San Francisco, San Francisco, California, USA.
TRACK-TBI Investigators
Neeraj BadjatiaNeurological Surgery, University of California San Francisco, San Francisco, California, USA.
Jason BarberNeurological Surgery, University of California San Francisco, San Francisco, California, USA.
Yelena G BodienNeurological Surgery, University of California San Francisco, San Francisco, California, USA.
Brian FabianNeurological Surgery, University of California San Francisco, San Francisco, California, USA.
Adam R FergusonNeurological Surgery, University of California San Francisco, San Francisco, California, USA.
Brandon ForemanNeurological Surgery, University of California San Francisco, San Francisco, California, USA.
Raquel C GardnerNeurological Surgery, University of California San Francisco, San Francisco, California, USA.
Shankar GopinathNeurological Surgery, University of California San Francisco, San Francisco, California, USA.
Ramesh GrandhiNeurological Surgery, University of California San Francisco, San Francisco, California, USA.
J Russell HuieNeurological Surgery, University of California San Francisco, San Francisco, California, USA.
C Dirk KeeneNeurological Surgery, University of California San Francisco, San Francisco, California, USA.
Hester F LingsmaNeurological Surgery, University of California San Francisco, San Francisco, California, USA.
Christine L MacDonaldNeurological Surgery, University of California San Francisco, San Francisco, California, USA.
Amy J MarkowitzNeurological Surgery, University of California San Francisco, San Francisco, California, USA.
Randall MerchantNeurological Surgery, University of California San Francisco, San Francisco, California, USA.
Laura B NgwenyaNeurological Surgery, University of California San Francisco, San Francisco, California, USA.
Richard B RodgersNeurological Surgery, University of California San Francisco, San Francisco, California, USA.
Andrea L C SchneiderNeurological Surgery, University of California San Francisco, San Francisco, California, USA.
David M SchnyerNeurological Surgery, University of California San Francisco, San Francisco, California, USA.
Sabrina R TaylorNeurological Surgery, University of California San Francisco, San Francisco, California, USA.
Nancy R TemkinNeurological Surgery, University of California San Francisco, San Francisco, California, USA.
Abel Torres-EspinNeurological Surgery, University of California San Francisco, San Francisco, California, USA.
Mary J VassarNeurological Surgery, University of California San Francisco, San Francisco, California, USA.
Kevin K W WangNeurological Surgery, University of California San Francisco, San Francisco, California, USA.
Justin C WongNeurological Surgery, University of California San Francisco, San Francisco, California, USA.
Ross D ZafonteNeurological Surgery, University of California San Francisco, San Francisco, California, USA.

Funding

Transforming Research and Clinical Knowledge in Traumatic Brain InjuryU01NS086090 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DIAZ-ARRASTIA, RAMON, GIACINO, JOSEPH THOMAS · 2013 to 2017
$19.1M
Skeletal Biology and Biomechanics (SBB) CoreP30AR075055 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EDWARD C HSIAO · 2019 to 2026
$7.1M
Transforming Traumatic Brain Injury Research and Clinical CareRC2NS069409 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MANLEY, GEOFFREY T · 2009 to 2011
$4.3M
NIAMS NIH HHS P30 AR075055NINDS NIH HHS RC2 NS069409NINDS NIH HHS U01 NS086090
6 · The paper itself

Abstract

abstractObjectives: An estimated 14-23% of patients with traumatic brain injury (TBI) incur multiple lifetime TBIs. The relationship between prior TBI and outcomes in patients with moderate to severe TBI (msTBI) is not well delineated. We examined the associations between prior TBI, in-hospital mortality, and outcomes up to 12 months after injury in a prospective US msTBI cohort. Methods: Data from hospitalized subjects with Glasgow Coma Scale score of 3-12 were extracted from the Transforming Research and Clinical Knowledge in Traumatic Brain Injury Study (enrollment period: 2014-2019). Prior TBI with amnesia or alteration of consciousness was assessed using the Ohio State University TBI Identification Method. Competing risk regressions adjusting for age, sex, psychiatric history, cranial injury and extracranial injury severity examined the associations between prior TBI and in-hospital mortality, with hospital discharged alive as the competing risk. Adjusted HRs (aHR (95% CI)) were reported. Multivariable logistic regressions assessed the associations between prior TBI, mortality, and unfavorable outcome (Glasgow Outcome Scale-Extended score 1-3 (vs. 4-8)) at 3, 6, and 12 months after injury. Results: Of 405 acute msTBI subjects, 21.5% had prior TBI, which was associated with male sex (87.4% vs. 77.0%, p=0.037) and psychiatric history (34.5% vs. 20.7%, p=0.010). In-hospital mortality was 10.1% (prior TBI: 17.2%, no prior TBI: 8.2%, p=0.025). Competing risk regressions indicated that prior TBI was associated with likelihood of in-hospital mortality (aHR=2.06 (1.01-4.22)), but not with hospital discharged alive. Prior TBI was not associated with mortality or unfavorable outcomes at 3, 6, and 12 months. Conclusions: After acute msTBI, prior TBI history is independently associated with in-hospital mortality but not with mortality or unfavorable outcomes within 12 months after injury. This selective association underscores the importance of collecting standardized prior TBI history data early after acute hospitalization to inform risk stratification. Prospective validation studies are needed. Level of evidence: IV. Trial registration number: NCT02119182.

Indexed as

mortalitypatient outcome assessmentrisk factortraumatic brain injury

Identifiers

PMID39081460
PMCPMC11287071

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.