Evidence map›Paper›PMID 39080977›Full record

ArticleAutism research : official journal of the International Society for Autism Research2025

Visual and auditory attention in individuals with DYRK1A and SCN2A disruptive variants.

Caitlin M Hudac, Kelsey Dommer, Monique Mahony, Trent D DesChamps, Brianna Cairney, Rachel Earl, Evangeline C Kurtz-Nelson, Jessica Bradshaw, Raphael A Bernier, Evan E Eichler and 3 more

Abstract read
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In one paragraph

Article in Autism research : official journal of the International Society for Autism Research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Visual function and autism spectrum disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
  2. Visual and auditory attention in individuals with DYRK1A and SCN2A disruptive variants.Autism research : official journal of the International Society for Autism Research · 2025
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Caitlin M HudacDepartment of Psychology, University of South Carolina, Columbia, South Carolina, USA.ORCID 0000-0002-0478-440X
Kelsey DommerCenter for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, Washington, USA.
Monique MahonyCenter for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, Washington, USA.
Trent D DesChampsDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA.
Brianna CairneyDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-7831-251X
Rachel EarlDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA.
Evangeline C Kurtz-NelsonDepartment of Pediatrics, Indiana University, Indianapolis, Indiana, USA.ORCID 0000-0002-9418-7915
Jessica BradshawDepartment of Psychology, University of South Carolina, Columbia, South Carolina, USA.ORCID 0000-0003-3003-3738
Raphael A BernierDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA.
Evan E EichlerDepartment of Genome Sciences, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-8246-4014
Emily NeuhausDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA.ORCID 0000-0003-1762-0348
Sara Jane WebbCenter for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, Washington, USA.ORCID 0000-0003-4101-6255
Frederick ShicCenter for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, Washington, USA.ORCID 0000-0002-9040-1259

Funding

Sporadic Mutations and Autism Spectrum DisordersR01MH101221 · NIMH · UNIVERSITY OF WASHINGTON · PI EICHLER, EVAN · 2013 to 2025
$9.2M
Phenotypic Characterization of Gene Disrupting Mutations in ASDR01MH100047 · NIMH · UNIVERSITY OF WASHINGTON · PI BERNIER, RAPHAEL A · 2014 to 2018
$2.1M
FamiliesSCN2A FoundationNIH HHS R01 MH100047NIH HHS R01 MH101221NIMH NIH HHS R01 MH100047NIMH NIH HHS R01 MH101221
6 · The paper itself

Abstract

This preliminary study sought to assess biomarkers of attention using electroencephalography (EEG) and eye tracking in two ultra-rare monogenic populations associated with autism spectrum disorder (ASD). Relative to idiopathic ASD (n = 12) and neurotypical comparison (n = 49) groups, divergent attention profiles were observed for the monogenic groups, such that individuals with DYRK1A (n = 9) exhibited diminished auditory attention condition differences during an oddball EEG paradigm whereas individuals with SCN2A (n = 5) exhibited diminished visual attention condition differences noted by eye gaze tracking when viewing social interactions. Findings provide initial support for alignment of auditory and visual attention markers in idiopathic ASD and neurotypical development but not monogenic groups. These results support ongoing efforts to develop translational ASD biomarkers within the attention domain.

Indexed as

AttentionAuditory PerceptionAutism Spectrum DisorderNAV1.2 Voltage-Gated Sodium ChannelProtein Serine-Threonine KinasesProtein-Tyrosine KinasesVisual PerceptionAdolescentAdultChildDyrk KinasesElectroencephalographyEye-Tracking TechnologyFemaleHumansMaleDyrk KinasesNAV1.2 Voltage-Gated Sodium ChannelProtein Serine-Threonine KinasesProtein-Tyrosine KinasesSCN2A protein, humanattentionautism spectrum disorder (ASD)conversational flowDYRK1Aelectroencephalography (EEG)eye trackinggenetic etiologySCN2Asocial attention

Identifiers

PMID39080977
PMCPMC11779982

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.