Evidence map›Paper›PMID 39080674›Full record

ArticleLipids in health and disease2024

Interaction between antiretroviral therapy regimens and body mass index on triglyceride levels in people living with HIV: a cross-sectional and longitudinal study.

Yide Xu, Bufeng Qi, Xiaolu Wu, Chen Lu, Pei Chen, Dongdong Wang, Xiaoting Li, Chunfeng Xie, Jieshu Wu, Caiyun Zhong and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lipids in health and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yide XuDepartment of Nutrition and Food Safety, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Bufeng QiDepartment of Nutrition and Food Safety, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Xiaolu WuDepartment of Nutrition and Food Safety, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Chen LuDepartment of Nutrition and Food Safety, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Pei ChenDepartment of Nutrition and Food Safety, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Dongdong WangDepartment of Nutrition and Food Safety, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Xiaoting LiDepartment of Nutrition and Food Safety, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Chunfeng XieDepartment of Nutrition and Food Safety, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Jieshu WuDepartment of Nutrition and Food Safety, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Caiyun ZhongDepartment of Nutrition and Food Safety, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Lin LiDepartment of Health Management Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, 211166, China.
Gu GaoDepartment of Health Management Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, 211166, China.
Dandan YangDepartment of Sexually Transmitted Diseases and AIDS, Center for Disease Control and Prevention of Jiangsu Province, Nanjing, 211166, China.
Ye DingDepartment of Maternal, Child and Adolescent Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China. dingye@njmu.edu.cn.
Shanshan GengDepartment of Nutrition and Food Safety, School of Public Health, Nanjing Medical University, Nanjing, 211166, China. gss9814@njmu.edu.cn.

Funding

National Natural Science Foundation of China 81872607
6 · The paper itself

Abstract

objectiveTo investigate how antiretroviral therapy (ART) regimens and body mass index (BMI) interact to affect triglyceride (TG) levels in people living with HIV (PLWH).

methodsThis research involved 451 men living with HIV for cross-sectional analysis, and 132 underwent follow-up assessments in 2021 and 2023. Multivariate logistic regression identified key factors, while covariance regression models assessed interactions between ART regimens and BMI on TG levels.

resultsThe result of this cross-sectional study indicated that advanced AIDS (acquired immune deficiency syndrome) stage (OR = 2.756, P = 0.003), higher BMI (OR = 1.131, P = 0.003), and waist-hip ratio (WHR, OR = 44.684, P = 0.019) are closely associated with high triglyceride levels. Additionally, regimens containing zidovudine (AZT) (OR = 3.927, P < 0.001) or protease inhibitors/integrase strand transfer inhibitors (PI/INSTI) (OR = 5.167, P < 0.001) were significantly linked to hypertriglyceridemia. Cross-sectional and longitudinal analyses from 2021 to 2023 emphasized that changes in BMI interact with antiretroviral treatment regimens to affect TG levels in PLWH (P

conclusionThe interaction between ART regimens and BMI influences TG levels in PLWH, indicating that weight management is crucial for reducing the risk of hypertriglyceridemia in this population.

Indexed as

Body Mass IndexHIV InfectionsTriglyceridesZidovudineAdultAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveCross-Sectional StudiesHumansHypertriglyceridemiaLongitudinal StudiesMaleMiddle AgedWaist-Hip RatioAnti-HIV AgentsTriglyceridesZidovudineAntiretroviral therapyBody mass indexInteractionTriglyceride

Identifiers

PMID39080674
PMCPMC11290172

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.