ArticleLipids in health and disease2024
Association between systemic immune-inflammation index and sarcopenic obesity in middle-aged and elderly Chinese adults: a cross-sectional study and mediation analysis.
Article in Lipids in health and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of sarcopenic obesity in adult patients with diabetes and associated factors: a systematic review and meta-analysis.Frontiers in nutrition · 2026Pooled it
- Pathological changes and therapeutic strategies for sarcopenia.EFORT open reviews · 2026Review
- Systemic inflammatory indices SIRI, AISI, and PWR are associated with sarcopenic obesity in middle-aged and older chinese adults: a cross-sectional study.Nutrition & metabolism · 2026Article
- The TyG Index and Obesity Indicators Predicting Low Muscle Mass in US Adults Without Diabetes: NHANES 2011-2018.Journal of nutrition and metabolism · 2026Article
- The Role of hs-CRP and Systemic Immune-Inflammation Index in Sarcopenia and Sarcopenic Obesity in Young Populations: Results from the National Health and Nutrition Examination Survey 2015-2018.Endocrine, metabolic & immune disorders drug targets · 2026Article
- Association of triglyceride-glucose index and atherogenic index of plasma with sarcopenia across different glucose metabolism states: the mediating role of oxidative stress and chronic inflammation.European journal of medical research · 2025Article
- Chained mediation of interleukins linking fluoride exposure to frailty: a cohort study of skeletal fluorosis patients in China.Environmental health : a global access science source · 2025Article
- Molecular Framework of the Onset and Progression of Skeletal Muscle Aging.International journal of molecular sciences · 2025Review
- A correlation study on triglyceride-glucose index and extensive neovascularization within carotid artery plaques.Diabetology & metabolic syndrome · 2025Article
- Associations of the Neutrophil-to-Lymphocyte Ratio(NLR), Triglyceride-Glucose Index (TyG), and TyG-derived indices with vitality decline in older adults in China: a study within the Integrated Care for Older People (ICOPE) framework.Lipids in health and disease · 2025Article
- Metabolic and Inflammatory Biomarkers Predicting Sarcopenic Obesity and Cardiometabolic Risk in Arab Women: A Cross-Sectional Study.International journal of molecular sciences · 2025Article
- Sarcopenic obesity in the Asia-Pacific region: Epidemiology, risk factors, and management.Osteoporosis and sarcopenia · 2025Review
- Use of Handgrip Strength as a Health Indicator in Public Sector Workers: A Cross-Sectional Study.Journal of functional morphology and kinesiology · 2025Article
- Age Difference in the Connection Between Systemic Inflammatory Response and Metabolic Syndrome.The Journal of clinical endocrinology and metabolism · 2025Article
- Integrated transcriptomic, proteomic, and metabolomic analysis unveils key roles of protein and nucleic acid interactions in diabetic ulcer pathogenesis.Frontiers in endocrinology · 2025Article
- Association between diverse obesity indicators and sleep quality in elderly Chinese people: a National Study.Frontiers in nutrition · 2024Article
- Associations of Obesity, Inflammatory Indicators, and Serum Testosterone in Adult Males: A Cross-Sectional Study Based on NHANES 2011-2016 and 2021-2023.American journal of men's healthArticle
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6 authors.
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Abstract
backgroundDespite the known association between chronic inflammation and reduced muscle mass, there is a gap in research regarding the association between the systemic immune-inflammation index (SII) and sarcopenic obesity (SO). This study aims to assess the relationship between SII and SO in middle-aged and elderly adults and the mediating role of triglyceride-glucose index (TyG).
methodsThis cross-sectional study involved 2,719 participants aged 45-90 years who underwent health check-ups. SO was evaluated by combining sarcopenia [assessed by handgrip strength and appendicular skeletal muscle index (ASMI)] with obesity (determined by body fat percentage). Association between SII and SO, sarcopenia, and obesity in middle-aged and elderly individuals was examined using multivariable logistic regression, restricted cubic spline analysis, and subgroup analysis. Bidirectional mediation analysis was conducted to determine the direct and indirect effects through SII and TyG.
resultsThe study included 2,719 participants, of which 228 had SO (8.4%). SO prevalence increased as the SII quartiles rose (P
conclusionsElevated levels of SII were associated with an increased risk of SO in middle-aged and elderly adults, especially in the elderly population, and elevated TyG levels played a role in this relationship.
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