ArticleReproductive biology and endocrinology : RB&E2024
Impact of elevated serum estradiol levels before progesterone administration on pregnancy outcomes in frozen-thawed embryo transfer for hormone replacement therapy.
Article in Reproductive biology and endocrinology : RB&E, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of Early-to-Mid-Luteal Serum Estradiol Levels with the Outcomes of Hormone Replacement Therapy-Frozen Embryo Transfer: A Systematic Review and Meta-Analysis.Reproductive sciences (Thousand Oaks, Calif.) · 2025Pooled it
- Follicular kisspeptin-VEGF axis in polycystic ovary syndrome and ovarian hyperstimulation syndrome.Journal of assisted reproduction and genetics · 2026Article
- Impact of estradiol-to-progesterone ratio before progesterone initiation on pregnancy outcomes in frozen embryo transfer cycles with hormone replacement therapy: an analysis of over 25,000 cycles.Frontiers in endocrinology · 2026Article
- Human placentation: foundations and implications for reproductive endocrinology and infertility.Systems biology in reproductive medicine · 2025Review
- Elevated serum estradiol levels on embryo transfer day predict higher pregnancy success in HRT-FET cycles.Reproductive biology and endocrinology : RB&E · 2025Article
- Serum estradiol on the day of final oocyte maturation and outcome of assisted reproduction in women with thyroid autoimmunity.Scientific reports · 2025Article
- Comparison of clinical pregnancy rates between hormone replacement therapy and modified natural cycle for endometrial preparation in frozen embryo transfer cycles: An RCT.International journal of reproductive biomedicine · 2025Article
- Clinical outcomes of different 17β-estradiol drug regimens and their impact on endometrial receptivity.Frontiers in endocrinology · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectiveThe objective of this retrospective cohort study is to investigate the impact of monitoring serum estradiol (E2) levels before progesterone administration within hormone replacement therapy (HRT) on pregnancy outcomes in women undergoing frozen-thawed embryo transfer (FET).
methodsAnalyzed HRT-FET cycles conducted at a reproductive center from 2017 to 2022. Serum E2 levels were measured prior to progesterone administration. Multivariate stratified and logistic regression analyses were performed on 26,194 patients grouped according to terciles of serum E2 levels before progesterone administration.
resultsThe clinical pregnancy rate (CPR) and live birth rate (LBR) exhibited a gradual decline with increasing serum E2 levels across the three E2 groups. Even after controlling for potential confounders, including female age, body mass index, infertility diagnosis, cycle category, number of embryos transferred, fertilization method, indication for infertility, and endometrial thickness, both CPR and LBR persistently showed a gradual decrease as serum E2 levels increased within the three E2 groups. The same results were obtained by multivariate logistic regression analysis.
conclusionsThis large retrospective study indicates that elevated serum E2 levels before progesterone administration during HRT-FET cycles are associated with reduced CPR and LBR post-embryo transfer. Therefore, it is advisable to monitor serum E2 levels and adjust treatment strategies accordingly to maximize patient outcomes.
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