Observational studyBMC infectious diseases2024
The performance of a combination of heparin-binding protein with other biomarkers for sepsis diagnosis: an observational cohort study.
Observational study in BMC infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- The influence of early serum heparin-binding protein (HBP) levels on the occurrence of sepsis in patients with severe burns.Journal of medical biochemistry · 2026Article
- Clinical diagnostic value of the plasma heparin binding protein in diabetic nephropathy patients comorbid with sepsis.Pakistan journal of medical sciences · 2026Article
- A Novel Composite Bioscore Integrating Biomarkers, Clinical Scores, and Comorbidity Indices for Prognostic Stratification in Sepsis.Journal of inflammation research · 2026Article
- Immune Biomarker Profiling Across Clinical States and Development of a SOFA-Integrated Model for 28-Day Mortality Prediction in Sepsis: A Prospective Cohort Study.Infection and drug resistance · 2026Article
- Heparin Binding Protein in Sepsis-A Comprehensive Overview of Pathophysiology, Clinical Usage and Utility as Biomarker.Biomedicines · 2025Review
- Biomarkers to guide sepsis management.Annals of intensive care · 2025Review
- A Web-Based Dynamic Nomogram for Early Diagnosis in Sepsis: Development and Validation with Real-World Clinical Utility.Infection and drug resistance · 2025Article
- Enhancing sepsis management: the role of dynamic heparin-binding protein monitoring in elderly patients.Frontiers in medicine · 2025Article
- Crossing Age Boundaries: The Unifying Potential of Presepsin in Sepsis Diagnosis Across Diverse Age Groups.Journal of clinical medicine · 2024Review
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
backgroundHBP, a novel biomarker released from neutrophils, may induce inflammatory responses and exacerbate vascular permeability, representing the pathophysiological characteristics of sepsis and septic shock. However, it remains uncertain whether the combination of HBP with other biomarkers yields enhanced diagnostic capacity for sepsis. We hypothesized that measurements included IL-6·IL-8·HBP, IL-6·IL-8·HBP/ALB and HBP/ALB which based on HBP will improve its diagnostic efficacy and even better than the traditional infection biomarkers.
methodsBetween July 2021 and June 2022, we carried out a comprehensive, multi-center, observational cohort study spanning six leading tertiary hospitals located in Heilongjiang Province, China. Patients were stratified into three categories based on the severity of infection: non-sepsis, sepsis, and septic shock. We collected clinical and laboratory data, along with infection and inflammation biomarkers, for analysis.
resultsA total of 195 patients were enrolled. Among the three groups, patients with septic shock (n = 75, 38.5%) had significantly higher baseline levels of HBP, WBC, Lac, CRP, PCT, IL-6, IL-8, and IL-10 compared to non-sepsis patients (n = 43, 22.0%) and sepsis patients (n = 77, 39.5%), with statistically significant differences (p < 0.05) observed for all parameters. When compared to SOFA score and traditional markers of CRP, PCT, IL-6 and IL-8, the combined indexes of IL-6·IL-8·HBP and IL-6·IL-8·HBP/ALB demonstrated significantly improved diagnostic performance for sepsis and septic shock (AUC 0.911 and 0.902 respectively, p < 0.001).
conclusionsThe combined measurements of IL-6·IL-8·HBP and IL-6·IL-8·HBP/ALB can augment the diagnostic capacity of HBP for sepsis, and offer reliable early supplementary indicators to traditional biomarkers for assessing disease severity in patients with infection.
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