Evidence map›Paper›PMID 39080536›Full record

Trial reportBMC anesthesiology2024

Efficacy of azasetron on postoperative chronic pain after pulmonary surgery: a randomized triple-blind controlled trial.

Yang Xu, Fei Jiang, Shengnan Shi, Hongyu Zheng, Xuhong Li, Xihong Ye, Xingrui Gong

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yang Xu *Institute of Neuroscience and Brain Disease, Department of Pain, Xiangyang Central Hospital, Hubei University of Arts and Science, Hubei, China.
Fei Jiang *Institute of Neuroscience and Brain Disease, Department of Anesthesiology, Xiangyang Central Hospital, Hubei University of Arts and Science, No.136. Jinzhou Street, Xiangcheng District, Xiangyang, 441000, China.
Shengnan ShiInstitute of Neuroscience and Brain Disease, Department of Anesthesiology, Xiangyang Central Hospital, Hubei University of Arts and Science, No.136. Jinzhou Street, Xiangcheng District, Xiangyang, 441000, China.
Hongyu ZhengInstitute of Neuroscience and Brain Disease, Department of Anesthesiology, Xiangyang Central Hospital, Hubei University of Arts and Science, No.136. Jinzhou Street, Xiangcheng District, Xiangyang, 441000, China.
Xuhong LiInstitute of Neuroscience and Brain Disease, Department of Anesthesiology, Xiangyang Central Hospital, Hubei University of Arts and Science, No.136. Jinzhou Street, Xiangcheng District, Xiangyang, 441000, China.
Xihong YeInstitute of Neuroscience and Brain Disease, Department of Anesthesiology, Xiangyang Central Hospital, Hubei University of Arts and Science, No.136. Jinzhou Street, Xiangcheng District, Xiangyang, 441000, China. yezi703@126.com.
Xingrui GongInstitute of Neuroscience and Brain Disease, Department of Anesthesiology, Xiangyang Central Hospital, Hubei University of Arts and Science, No.136. Jinzhou Street, Xiangcheng District, Xiangyang, 441000, China. gongxrhbxy@sohu.com.

Funding

Natural Science Foundation of Hubei Province 2023AFD041Natural Science Foundation of Xiangyang (2021YL017)
6 · The paper itself

Abstract

backgroundInhibition of 5-HT3 (5-Hydroxyl Tryptamine) receptors is known to enhance morphine analgesia in animal models. We tested the efficacy of azasetron, a 5-HT3 receptor antagonist, on postoperative chronic pain after pulmonary surgery in a randomized triple-blind controlled study.

methodsA total of 250 patients who were scheduled to receive pulmonary surgery were randomized to patient-controlled analgesia (PCA) using 200 µg sufentanil with normal saline or 200 µg sufentanil with 20 mg azasetron. The numerical rating scale of pain (NRS) was recorded at baseline, postoperative day (POD) 1, 2, 3, 90, and 180. Negative binomial regression was used to identify associated factors for postoperative NRS six months after surgery.

resultsThe results showed that azasetron did not affect the primary outcomes: the incidence of postoperative chronic pain on POD90 and 180. However, azasetron decreased postoperative NRS at rest and activity on POD1, 2, and 3. Furthermore, azasetron decreased postoperative nausea and vomiting on POD1 and 2. Univariate and multivariate negative binomial regression analysis identified preoperative pain, smoking, drinking and open surgery are risk factors of chronic pain six months after surgery.

conclusionsAzasetron did not affect the incidence of chronic pain after pulmonary surgery. The presence of preoperative pain, smoking, drinking, and open surgery were found to be associated with chronic pain six months after surgery. CLINICAL

trial registrationThe trial was registered prior to patient enrollment at the Chinese Clinical Trial Registry (ChiCTR2200060139), 20/05/2022; the site url is https://www.chictr.org.cn/ .

Indexed as

Analgesia, Patient-ControlledBenzamidesChronic PainOxazinesPostoperative PainAdultAgedAnalgesics, OpioidBridged Bicyclo Compounds, HeterocyclicDouble-Blind MethodFemaleHumansLungMaleMiddle AgedSerotonin 5-HT3 Receptor AntagonistsAnalgesics, OpioidazasetronBenzamidesBridged Bicyclo Compounds, HeterocyclicOxazinesSerotonin 5-HT3 Receptor AntagonistsAcute painAzasetronChronic painPulmonary surgery

Identifiers

PMID39080536
PMCPMC11290065

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.