ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2024
Punishment-resistant alcohol intake is mediated by the nucleus accumbens shell in female rats.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Article
- Sex-dependent role of the ventral hippocampus, but not its projection to the medial prefrontal cortex, in a novel operant conflict-driven ethanol choice task.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Anterior Insula Activity during Alcohol and Social Reward Self-Administration and Choice in Male and Female Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Prelimbic cortex, but not its nucleus reuniens projections, regulates punished alcohol self-administration.Neuropharmacology · 2026Article
- Sex-Specific patterns of vulnerability to alcohol addiction-like behaviors in rats.Translational psychiatry · 2026Article
- Individual differences in punished alcohol self-administration are unaltered by alcohol vapor exposure.Alcohol (Fayetteville, N.Y.) · 2025Observational
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
Abstract
Alcohol use is widespread across many societies. While most people can control their alcohol use, a vulnerable sub-population develops alcohol use disorder, characterized by continued alcohol use despite negative consequences. We used a rat model of alcohol self-administration despite negative consequences to identify brain activity associated with this addiction-like behaviour. We and others have previously shown that response-contingent punishment of alcohol self-administration with mild footshock reliably identifies two sub-populations. One group substantially decreases alcohol self-administration in the face of punishment (punishment-sensitive, controlled) and another group continues alcohol self-administration despite negative consequences (punishment-resistant, addiction-like behaviour). In this study, we aimed to validate this model in females and identify associated brain regions. We trained Long-Evans outbred rats (n = 96) to self-administer 20% ethanol, and then introduced response-contingent footshock. We found that female rats consumed more alcohol in unpunished and punished sessions compared to male rats. In one group of rats (n = 24, m/f), we identified neuronal activity associated with punishment-resistant alcohol self-administration using the neurobiological marker of activity cFos. We found lower cFos expression in NAcSh associated with punishment-resistant alcohol self-administration. In another group of rats (n = 72, m/f), we used chemogenetic inhibition of NAcSh during punished alcohol self-administration. We found that chemogenetic NAcSh inhibition had no effect on unpunished alcohol self-administration but selectively increased punished alcohol self-administration in punishment-resistant female rats. These results indicate that more female rats develop punishment-resistant alcohol consumption, and that NAcSh hypofunction may underlie this phenotype.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.