Evidence map›Paper›PMID 39080193›Full record

ReviewCurrent treatment options in oncology2024

Opportunities and Challenges in Soft Tissue Sarcoma Risk Stratification in the Era of Personalised Medicine.

Avirup Chowdhury, Khin Thway, Sandro Pasquali, Dario Callegaro, Alessandro Gronchi, Robin L Jones, Paul H Huang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current treatment options in oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Sarcoma: Last Year's Practice Changing Papers.Annals of surgical oncology · 2025
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Avirup ChowdhuryDivision of Molecular Pathology, The Institute of Cancer Research, 15 Cotswold Road Sutton, London, SM2 5NG, UK.
Khin ThwayDivision of Molecular Pathology, The Institute of Cancer Research, 15 Cotswold Road Sutton, London, SM2 5NG, UK.
Sandro PasqualiMolecular Pharmacology, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy.
Dario CallegaroDepartment of Surgery, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy.
Alessandro GronchiDepartment of Surgery, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy.
Robin L JonesThe Royal Marsden NHS Foundation Trust, London, UK.
Paul H HuangDivision of Molecular Pathology, The Institute of Cancer Research, 15 Cotswold Road Sutton, London, SM2 5NG, UK. paul.huang@icr.ac.uk.

Funding

Cancer Research UK C56167/A29363Cancer Research UK SEBSTF-2021\100004Fondazione AIRC per la ricerca sul cancro ETS 24297Fundación Científica Asociación Española Contra el Cáncer AECC-GEACC19007MA
6 · The paper itself

Abstract

opinion statementSoft tissue sarcomas (STS) are a rare and heterogeneous group of cancers. Treatment options have changed little in the past thirty years, and the role of neoadjuvant chemotherapy is controversial. Accurate risk stratification is crucial in STS in order to facilitate clinical discussions around peri-operative treatment. Current risk stratification tools used in clinic, such as Sarculator, use clinicopathological characteristics and may be specific to anatomical site or to histology. More recently, risk stratification tools have been developed using molecular or immunological data. Combining Sarculator with other risk stratification tools may identify novel patient groups with differential clinical outcomes. There are several considerations when translating risk stratification tools into widespread clinical use, including establishing clinical utility, health economic value, being applicable to existing clinical pathways, having strong real-world performance, and being supported by investment into infrastructure. Future work may include incorporation of novel modalities and data integration techniques.

Indexed as

Clinical Decision-MakingPrecision MedicineRisk AssessmentSarcomaSoft Tissue NeoplasmsCost-Benefit AnalysisDiagnosis, DifferentialHumansNomogramsBiomarkersPersonalised medicineRisk stratificationSoft tissue sarcomasTumour heterogeneity

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.