Evidence map›Paper›PMID 39080095›Full record

ArticleUpdates in surgery2024

Cornerstones and divergencies in the implementation and use of liver hypertrophy techniques: results from a nationwide survey for the set-up of the prospective registry.

Francesca Ratti, Matteo Serenari, Alfonso Avolio, Giacomo Batignani, Ugo Boggi, Alberto Brolese, Lucio Caccamo, Andrea Celotti, Umberto Cillo, Nicola Cinardi and 39 more

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Article in Updates in surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

49 authors.

Francesca Ratti *Hepatobiliary Surgery Division, IRCCS San Raffaele Scientific Institute, Milan, Italy. ratti.francesca@hsr.it.ORCID http://orcid.org/0000-0002-8108-9064
Matteo Serenari *Hepato-Biliary Surgery and Transplant Unit, IRCCS, Azienda Ospedaliero-Universitaria Di Bologna, Sant'Orsola-Malpighi Hospital, Bologna, Italy.
Alfonso AvolioGeneral Surgery and Liver Transplantation, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Giacomo BatignaniDepartment of Experimental and Clinical Medicine, Hepatobiliary Pancreatic Surgery, University of Florence, Florence, Italy.
Ugo BoggiDepartment of Surgery, University Hospital of Pisa, Pisa, Italy.
Alberto BroleseDepartment of General Surgery and Hepato-Pancreato-Biliary (HPB) Unit-APSS, Trento, Italy.
Lucio CaccamoUnit of General Surgery and Liver Transplantation, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Andrea CelottiDepartment of Surgery, ASST Cremona, Cremona, CR, Italy.
Umberto CilloGeneral Surgery 2-Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, Padua University Hospital, Padua, Italy.
Nicola CinardiHepato-Pancreato-Biliary (HPB) Surgery Unit Azienda Di Rilevanza Nazionale e Alta Specializzazione (ARNAS) Garibaldi-PO "Nesima", 95100, Catania, Italy.
Christian CotsoglouGeneral Surgery Unit, IRCCS San Gerardo Dei Tintori, Monza, Italy.
Raffaele Dalla ValleHepatobiliary Surgery Unit Department of Medicine and Surgery, University of Parma, Parma, Italy.
Luciano De CarlisDepartment of General Surgery and Transplantation, School of Medicine, University of Milano-Bicocca, Niguarda Hospital, Milan, Italy.
Paolo De SimoneDivision of Hepatic Surgery and Liver Transplantation, University of Pisa Medical School Hospital, Pisa, Italy.
Fabrizio Di BenedettoHepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, University of Modena and Reggio Emilia, Modena, Italy.
Giorgio ErcolaniDepartment of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Giuseppe Maria EttorreDepartment of Surgery, San Camillo Forlanini Hospital, Rome, Italy.
Massimo FediHepatobiliary Surgery Unit, USL Toscana Centro-San Jacopo Hospital, Pistoia, Italy.
Alessandro FerreroDepartment of Surgery, Mauriziano Hospital, Turin, Italy.
Antonio GiulianiUnit of General Surgery, San Giuseppe Moscati Hospital, Aversa, Italy.
Felice GiulianteHepatobiliary Surgery Unit, Fondazione Policlinico Universitario A. Gemelli IRCSS, Università Cattolica del Sacro Cuore, Rome, Italy.
Gian Luca GraziDepartment of Experimental and Clinical Medicine, Hepatobiliary Pancreatic Surgery, University of Florence, Florence, Italy.
Salvatore GruttadauriaDepartment for the Treatment and Study of Abdominal Diseases and Abdominal Transplantation, Istituto Di Ricovero E Cura a Carattere Scientifico-Istituto Mediterraneo Per I Trapianti E Terapie Ad Alta Specializzazione (IRCCS-ISMETT), 90127, Palermo, Italy.
Alfredo GuglielmiDepartment of Surgery, Dentistry, Gynecology and Pediatrics, Division of General and Hepatobiliary Surgery, University of Verona, G.B. Rossi University Hospital, Verona, Italy.
Francesco IzzoDivision of Surgical Oncology, Hepatobiliary Unit, Istituto Nazionale Tumori IRCCS Fondazione "G. Pascale" Napoli, Naples, Italy.
Quirino LaiGeneral Surgery and Organ Transplantation Unit, AOU Policlinico Umberto I, Sapienza University of Rome, 00161, Rome, Italy.
Dario LorenzinGeneral Surgery Clinic and Liver Transplant Center, University Hospital of Udine, Udine, Italy.
Marcello MaestriDivision of General Surgery 1, Department of Surgery, Fondazione IRCCS Policlinico San Matteo, 27100, Pavia, Italy.
Marco MassaniRegional Center for HPB Surgery, Regional Hospital of Treviso, Treviso, Italy.
Vincenzo MazzaferroDepartment of Surgery, Division of HPB Surgery and Liver Transplantation, Fondazione IRCCS Istituto Nazionale Tumori Di Milano, Milan, Italy.
Riccardo MemeoDepartment of Hepato-Pancreato-Biliary Surgery, "F. Miulli" General Regional Hospital, Acquaviva Delle Fonti, Bari, Italy.
Bruno NardoDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Rende, Italy.
Nazario PortolaniDepartment of Clinical and Experimental Sciences, Surgical Clinic, University of Brescia, Brescia, Italy.
Matteo RavaioliHepato-Biliary Surgery and Transplant Unit, IRCCS, Azienda Ospedaliero-Universitaria Di Bologna, Sant'Orsola-Malpighi Hospital, Bologna, Italy.
Aldo RoccaDepartment of Medicine and Health Sciences "V. Tiberio", University of Molise, Campobasso, Italy.
Renato RomagnoliGeneral Surgery 2U-Liver Transplant Unit, Molinette Hospital, Azienda Ospedaliero Universitaria Città Della Salute E Della Scienza Di Torino, Università Di Torino, Turin, Italy.
Fabrizio RomanoSchool of Medicine and Surgery, University of Milan Bicocca, HPB Surgery, Fondazione IRCCS San Gerardo, Monza, Italy.
Edoardo SaladinoOncological Surgical Unit, Papardo Hospital, Messina, Italy.
Giuseppe TisoneDepartment of Surgical Sciences and Medical Sciences, University of Rome-Tor Vergata, Rome, Italy.
Roberto TroisiDivision of HPB, Minimally Invasive and Robotic Surgery, Transplantation Service, Federico II University Hospital Naples, Naples, Italy.
Luigi VeneroniGeneral Surgery Division, Ospedale Infermi, Rimini, Italy.
Giovanni VennarecciDepartment of Hepatobiliary and Liver Transplantation Surgery, A.O.R.N. Cardarelli, Naples, Italy.
Luca ViganòDivision of Surgery, Humanitas Gavazzeni Hospital, Bergamo, Italy.
Giuseppe ViolaChirurgia Generale Azienda Ospedaliera Card. G. Panico, Tricase, Italy.
Marco VivarelliHPB Surgery and Transplantation Unit, Department of Clinical and Experimental Medicine, Polytechnic University of Marche, Ancona, Italy.
Giacomo ZanusDepartment of Surgery, Oncology and Gastroenterology - DISCOG, University of Padua, Padua, Italy.
Luca Aldrighetti *Hepatobiliary Surgery Division, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Elio Jovine *Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
IGROWtoH (Italian Group of Regenerative, Occlusive Worldwide-used Techniques Of hepatic Hypertrophy) group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this national survey on liver hypertrophy techniques was to track the trends of their use and implementation in Italy and to detect analogies and heterogeneities among centers.

methodsIn December 2022, Italian centers with liver resection activity were specifically contacted and asked to fill an online questionnaire composed of 6 sections including a total of 51 questions.

results46 Italian centers filled the questionnaire. The proportion of major/total number of liver resections was 27% and the use of hypertrophy techniques was required in 6,2% of cases. The most frequent reason of drop out was disease progression in 58.5% of cases. Most frequently used techniques were PVE and ALPPS with an increasing use of hepatic venous deprivation (HVD). Heterogeneous answers were provided regarding the cutoff values to indicate the need for hypertrophy techniques. Criteria to allocate a patient to different hypertrophy techniques are not standardized.

conclusionsThe use of hypertrophy techniques is deep-rooted in Italy, documenting the established value of their role in improving resectability rate. While an evolution of techniques is detectable, still significant heterogeneity is perceived in terms of cutoff values, indications and managing protocols.

Indexed as

HepatectomyLiverRegistriesDisease ProgressionHumansHypertrophyItalyLiver NeoplasmsProspective StudiesSurveys and QuestionnairesHypertrophy techniquesLiver failureLiver surgeryMorbiditySurvey

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.