Evidence map›Paper›PMID 39080077›Full record

ReviewJournal of cancer research and clinical oncology2024

Advances in the understanding of nuclear pore complexes in human diseases.

Yuxuan Li, Jie Zhu, Fengguang Zhai, Lili Kong, Hong Li, Xiaofeng Jin

Abstract readReview
In one paragraph

Review in Journal of cancer research and clinical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yuxuan Li *The Affiliated Lihuili Hospital of Ningbo University, Ningbo, 315040, Zhejiang, China.
Jie Zhu *The Affiliated Lihuili Hospital of Ningbo University, Ningbo, 315040, Zhejiang, China.
Fengguang Zhai *Department of Biochemistry and Molecular Biology, and Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Nngbo University, Ningbo, 315211, Zhejiang, China.
Lili KongDepartment of Biochemistry and Molecular Biology, and Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Nngbo University, Ningbo, 315211, Zhejiang, China.
Hong LiThe Affiliated Lihuili Hospital of Ningbo University, Ningbo, 315040, Zhejiang, China. lancet2010@aliyun.com.
Xiaofeng JinThe Affiliated Lihuili Hospital of Ningbo University, Ningbo, 315040, Zhejiang, China. jinxiaofeng@nbu.edu.cn.

Funding

the General Surgery Clinical Key Specialty Construction Project of Zhejiang Province 2023-SZZthe National Natural Science Foundation of China 32270821the Natural Science Foundation of Ningbo 2021J294the Ningbo Public Welfare Science & Technology Major Project 2021S106the Project of Zhejiang Medical and Health Platform Plan 2022KY1079the Youth Science and technology innovation leader of Ningbo 2023QL052
6 · The paper itself

Abstract

backgroundNuclear pore complexes (NPCs) are sophisticated and dynamic protein structures that straddle the nuclear envelope and act as gatekeepers for transporting molecules between the nucleus and the cytoplasm. NPCs comprise up to 30 different proteins known as nucleoporins (NUPs). However, a growing body of research has suggested that NPCs play important roles in gene regulation, viral infections, cancer, mitosis, genetic diseases, kidney diseases, immune system diseases, and degenerative neurological and muscular pathologies. PURPOSE: In this review, we introduce the structure and function of NPCs. Then We described the physiological and pathological effects of each component of NPCs which provide a direction for future clinical applications.

methodsThe literatures from PubMed have been reviewed for this article.

conclusionThis review summarizes current studies on the implications of NPCs in human physiology and pathology, highlighting the mechanistic underpinnings of NPC-associated diseases.

Indexed as

Nuclear PoreNuclear Pore Complex ProteinsHumansKidney DiseasesNeoplasmsNuclear Pore Complex ProteinsCancersDiseasesNuclear pore complexesNucleoporin

Identifiers

PMID39080077
PMCPMC11289042

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.