Evidence map›Paper›PMID 39079718›Full record

ArticleMolecular pharmacology2024

Aulosirazole Stimulates FOXO3a Nuclear Translocation to Regulate Apoptosis and Cell-Cycle Progression in High-Grade Serous Ovarian Cancer (HGSOC) Cells.

Manead Khin, Lydia J Davis, Daniel D Lantvit, Jimmy Orjala, Joanna E Burdette

Abstract read
In one paragraph

Article in Molecular pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. [Role and mechanisms of FoxO3a-related signaling pathways in breast cancer cell apoptosis].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Manead KhinDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois (M.K., D.D.L., J.O., J.E.B.); and Department of Chemistry and Biochemistry, University of North Carolina Wilmington, Wilmington, North Carolina (L.J.D.).ORCID 0000-0002-5744-9584
Lydia J DavisDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois (M.K., D.D.L., J.O., J.E.B.); and Department of Chemistry and Biochemistry, University of North Carolina Wilmington, Wilmington, North Carolina (L.J.D.).ORCID 0000-0002-0898-7191
Daniel D LantvitDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois (M.K., D.D.L., J.O., J.E.B.); and Department of Chemistry and Biochemistry, University of North Carolina Wilmington, Wilmington, North Carolina (L.J.D.).
Jimmy OrjalaDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois (M.K., D.D.L., J.O., J.E.B.); and Department of Chemistry and Biochemistry, University of North Carolina Wilmington, Wilmington, North Carolina (L.J.D.).
Joanna E BurdetteDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois (M.K., D.D.L., J.O., J.E.B.); and Department of Chemistry and Biochemistry, University of North Carolina Wilmington, Wilmington, North Carolina (L.J.D.) joannab@uic.edu.

Funding

Project 3:Isolation Chemistry of Filamentous Fungi and Biological EvaluationP01CA125066 · NCI · OHIO STATE UNIVERSITY · PI JIMMY ORJALA · 2007 to 2026
$27.2M
Microfluidic Models of Ovarian Cancer Preneoplastic LesionsR01CA240301 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Joanna E Burdette, Jonathan Coppeta · 2019 to 2026
$4.6M
Research Training in Natural Product Complementary and Integrative HealthT32AT007533 · NCCIH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Joanna E Burdette, JIMMY ORJALA · 2013 to 2026
$4.3M
Imaging mass spectrometry methodologies for studying the metabolites of cancer metastasisR01CA240423 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BURDETTE, JOANNA E, SANCHEZ, LAURA MARGARET · 2020 to 2024
$2.1M
NCCIH NIH HHS T32 AT007533NCI NIH HHS P01 CA125066NCI NIH HHS R01 CA240301NCI NIH HHS R01 CA240423
6 · The paper itself

Abstract

Ovarian cancer, the fifth leading cause of cancer-related mortality in women, is the most lethal gynecological malignancy globally. Within various ovarian cancer subtypes, high-grade serous ovarian cancer is the most prevalent and there is frequent emergence of chemoresistance. Aulosirazole, an isothiazolonaphthoquinone alkaloid, isolated from the cyanobacterium

Indexed as

ApoptosisForkhead Box Protein O3Ovarian NeoplasmsAnimalsCell CycleCell Line, TumorCell NucleusCell ProliferationCystadenocarcinoma, SerousFemaleHumansMiceMice, NudeXenograft Model Antitumor AssaysForkhead Box Protein O3FOXO3 protein, human

Identifiers

PMID39079718
PMCPMC11331498

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.