Evidence map›Paper›PMID 39079399›Full record

ReviewCurrent opinion in microbiology2024

New developments in Aspergillus fumigatus and host reactive oxygen species responses.

Matthew R James, Katherine E Doss, Robert A Cramer

Abstract readReview
In one paragraph

Review in Current opinion in microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Trans-Kingdom dsRNA Sensing:bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Article
  7. Glutathione impacts bothbioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. A roadmap to chemically reactive species: how diverse oxidants affectMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Matthew R JamesGeisel School of Medicine, Department of Microbiology and Immunology, Dartmouth College, Hanover, New Hampshire, USA.
Katherine E DossGeisel School of Medicine, Department of Microbiology and Immunology, Dartmouth College, Hanover, New Hampshire, USA.
Robert A CramerGeisel School of Medicine, Department of Microbiology and Immunology, Dartmouth College, Hanover, New Hampshire, USA. Electronic address: Robert.a.cramer.jr@dartmouth.edu.

Funding

Understanding the role of RNA-binding protein mutations in cancerP20GM113132 · NIGMS · DARTMOUTH COLLEGE · PI MIERKE, DALE F · 2016 to 2025
$25.9M
Translational Research CoreP30DK117469 · NIDDK · DARTMOUTH COLLEGE · PI DEBORAH A HOGAN · 2018 to 2026
$13.9M
Evolution of Aspergillus fumigatus virulenceR01AI130128 · NIAID · DARTMOUTH COLLEGE · PI Robert Andrew Cramer · 2017 to 2026
$4.5M
Antifungal Immunity and the Mechanism of Fungal Programmed Cell DeathR01AI139632 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI CRAMER, ROBERT ANDREW, HOHL, TOBIAS M · 2019 to 2023
$3.3M
Environmental Oxygen Transitions and Aspergillosis Disease ProgressionR01AI146121 · NIAID · DARTMOUTH COLLEGE · PI CRAMER, ROBERT ANDREW · 2019 to 2023
$2.6M
Optimization and chemical biology of novel antifungals to combat azole resistant mould infectionsR01AI181215 · NIAID · DARTMOUTH COLLEGE · PI Robert Andrew Cramer · 2024 to 2026
$2.3M
NIAID NIH HHS R01 AI130128NIAID NIH HHS R01 AI139632NIAID NIH HHS R01 AI146121NIAID NIH HHS R01 AI181215NIDDK NIH HHS P30 DK117469NIGMS NIH HHS P20 GM113132
6 · The paper itself

Abstract

Aspergillus fumigatus is a filamentous fungus abundant in the environment and the most common causative agent of a spectrum of human diseases collectively termed aspergillosis. Invasive pulmonary aspergillosis is caused by deficiencies in innate immune function that result in the inability of the host to clear inhaled Aspergillus conidia that then germinate and form invasive hyphae. Myeloid cells, and their ability to generate reactive oxygen species (ROS), are essential for conidia clearance from the host. To combat ROS, A. fumigatus employs an expansive antioxidant system, though how these canonical antioxidant mechanisms contribute to infection initiation and disease progression remain to be fully defined. Recent research has identified noncanonical pathways in the A. fumigatus ROS response and new host populations with ROS deficiencies that are at-risk for invasive aspergillosis. Here, we highlight recent developments in the understanding of ROS at the interface of the dynamic A. fumigatus-host interaction.

Indexed as

Aspergillus fumigatusHost-Pathogen InteractionsReactive Oxygen SpeciesAnimalsAspergillosisHumansImmunity, InnateSpores, FungalReactive Oxygen Species

Identifiers

PMID39079399
PMCPMC11475146

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.