Evidence map›Paper›PMID 39079133›Full record

Trial reportThe Journal of international medical research2024

The therapeutic effect of levosimendan in patients with prolonged ventilator weaning and cardiac dysfunction.

Fang Xiong, Zongjun Hu, Chao Liu, Kexiang Zhang, Qilong Zhou, Jianguo Chen, Hua Lu, Xi Yue, Jianxin Zhao, Pengfei Pan

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of international medical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fang XiongPostgraduate School, Jinzhou Medical University, Jinzhou, Liaoning, China.
Zongjun HuDepartment of Critical Care Medicine, Chongqing University Three Gorges Hospital, Wanzhou, Chongqing, China.
Chao LiuDepartment of Critical Care Medicine, Chongqing University Three Gorges Hospital, Wanzhou, Chongqing, China.
Kexiang ZhangDepartment of Critical Care Medicine, Chongqing University Three Gorges Hospital, Wanzhou, Chongqing, China.
Qilong ZhouDepartment of Critical Care Medicine, Chongqing University Three Gorges Hospital, Wanzhou, Chongqing, China.
Jianguo ChenDepartment of Critical Care Medicine, Chongqing University Three Gorges Hospital, Wanzhou, Chongqing, China.
Hua LuDepartment of Critical Care Medicine, Chongqing University Three Gorges Hospital, Wanzhou, Chongqing, China.
Xi YueDepartment of Critical Care Medicine, Chongqing University Three Gorges Hospital, Wanzhou, Chongqing, China.
Jianxin ZhaoDepartment of Critical Care Medicine, Chongqing University Three Gorges Hospital, Wanzhou, Chongqing, China.
Pengfei PanDepartment of Critical Care Medicine, Chongqing University Three Gorges Hospital, Wanzhou, Chongqing, China.ORCID 0000-0002-7024-3863

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the therapeutic effect of levosimendan in patients with prolonged ventilator weaning and cardiac dysfunction.

methodPatients with prolonged ventilator weaning and cardiac dysfunction were randomly allocated to receive conventional treatment (control group) or intravenous infusion of levosimendan for 24 h based on conventional treatment (levosimendan group). Weaning success rates were then compared between the two groups. The study was retrospectively registered with Research Registry (ID No. researchregistry10304).

resultsA total of 40 patients were included (20 per group). Within 3 days after initiation of treatment, significantly more cases were successfully weaned in the levosimendan group versus control group (eight versus four cases, respectively). Among the eight patients who underwent pulse indicator continuous cardiac output monitoring in the levosimendan group, the global ejection fraction increased 24 h after treatment, and the cardiac function index and cardiac index increased 72 h after treatment.

conclusionFor patients requiring prolonged mechanical ventilation who have concomitant cardiac dysfunction, levosimendan may be considered to increase the probability of weaning success.

Indexed as

SimendanVentilator WeaningAgedCardiotonic AgentsFemaleHeart DiseasesHumansMaleMiddle AgedPyridazinesRespiration, ArtificialRetrospective StudiesTreatment OutcomeCardiotonic AgentsPyridazinesSimendanCardiac dysfunctionLevosimendanMechanical ventilationProlonged ventilator weaningPulse indicator continuous cardiac output monitoringWeaning

Identifiers

PMID39079133
PMCPMC11295236

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.