Evidence map›Paper›PMID 39079063›Full record

ArticleJournal of the American Chemical Society2024

Development of a Novel Amplifiable System to Quantify Hydrogen Peroxide in Living Cells.

Lingfei Wang, Hanfeng Lin, Bin Yang, Xiqian Jiang, Jianwei Chen, Sandipan Roy Chowdhury, Ninghui Cheng, Paul A Nakata, David M Lonard, Meng C Wang and 1 more

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lingfei WangVerna and Marrs McLean Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, Texas 77030, United States.
Hanfeng LinVerna and Marrs McLean Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, Texas 77030, United States.
Bin YangVerna and Marrs McLean Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, Texas 77030, United States.
Xiqian JiangVerna and Marrs McLean Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, Texas 77030, United States.ORCID 0000-0001-5568-3417
Jianwei ChenVerna and Marrs McLean Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, Texas 77030, United States.
Sandipan Roy ChowdhuryVerna and Marrs McLean Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, Texas 77030, United States.
Ninghui ChengDepartment of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, United States.
Paul A NakataDepartment of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, United States.
David M LonardDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, United States.
Meng C WangDepartment of Molecular and Human Genetics, Huffington Center on Aging, and Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, United States.
Jin WangVerna and Marrs McLean Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, Texas 77030, United States.ORCID 0000-0003-3625-7919

Funding

Reversible Covalent BTK Degraders as the Next Generation Targeted Therapy to Treat B-cell MalignanciesR01CA250503 · NCI · BAYLOR COLLEGE OF MEDICINE · PI WANG, JIN, WANG, MICHAEL · 2020 to 2024
$3.4M
REAL-TIME QUANTITATIVE IMAGING OF INTRACELLULAR BIOTHIOL DYNAMICSR01GM115622 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI WANG, JIN · 2015 to 2019
$1.6M
NCI NIH HHS R01 CA250503NIGMS NIH HHS R01 GM115622
6 · The paper itself

Abstract

Although many redox signaling molecules are present at low concentrations, typically ranging from micromolar to submicromolar levels, they often play essential roles in a wide range of biological pathways and disease mechanisms. However, accurately measuring low-abundant analytes has been a significant challenge due to the lack of sensitivity and quantitative capability of existing measurement methods. In this study, we introduced a novel chemically induced amplifiable system for quantifying low-abundance redox signaling molecules in living cells. We utilized H

Indexed as

Hydrogen PeroxideReceptors, AndrogenHumansOxidation-ReductionHydrogen PeroxideReceptors, Androgen

Identifiers

PMID39079063
PMCPMC11722959

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.