Evidence map›Paper›PMID 39078535›Full record

SynthesisJournal of thrombosis and thrombolysis2024

Direct oral anticoagulants in embolic stroke of undetermined source: an updated meta-analysis.

Gabriel Marinheiro, Beatriz Araújo, André Rivera, Gabriel de Almeida Monteiro, Laís Silva Santana, Marianna Leite, Antonio Mutarelli, Agostinho C Pinheiro, Eberval Gadelha Figueiredo, João Paulo Mota Telles

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of thrombosis and thrombolysis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Gabriel MarinheiroSchool of Medicine, Federal University of Ceará, Sobral, Ceará, Brazil. gabrielmarinheirosb@gmail.com.ORCID http://orcid.org/0009-0001-8040-6515
Beatriz AraújoDepartment of Medicine, Nove de Julho University, São Bernardo do Campo, Brazil.
André RiveraDepartment of Medicine, Nove de Julho University, São Bernardo do Campo, Brazil.
Gabriel de Almeida MonteiroSchool of Medicine, Federal University of Ceará, Sobral, Ceará, Brazil.
Laís Silva SantanaSchool of Medicine, University of São Paulo, São Paulo, Brazil.
Marianna LeiteSchool of Medicine, Santa Marcelina College, São Paulo, Brazil.
Antonio MutarelliSchool of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Agostinho C PinheiroDepartment of Neurology, Massachusetts General Hospital, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
Eberval Gadelha FigueiredoDepartment of Neurosurgery, University of São Paulo, São Paulo, Brazil.
João Paulo Mota TellesDepartment of Neurology, University of São Paulo, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The efficacy and safety of direct oral anticoagulants (DOAC) in patients with embolic stroke of undetermined source (ESUS) remains unclear. We systematically searched PubMed, Embase, and Cochrane Library for randomized controlled trials (RCT) comparing DOACs versus aspirin in patients with ESUS. Risk ratios (RR) and 95% confidence intervals (CI) were computed for binary endpoints. Four RCTs comprising 13,970 patients were included. Compared with aspirin, DOACs showed no significant reduction of recurrent stroke (RR 0.95; 95% CI 0.84-1.09; p = 0.50; I

Indexed as

AnticoagulantsAspirinEmbolic StrokeAdministration, OralHemorrhageHumansRandomized Controlled Trials as TopicRecurrenceAnticoagulantsAspirinCryptogenic strokeDirect oral anticoagulantDOACESUSMeta-analysisStroke

Identifiers

PMID39078535

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.