Evidence map›Paper›PMID 39078429›Full record

ArticleVirchows Archiv : an international journal of pathology2025

Novel dual gene fusions identified in a late pulmonary metastasis of an infantile fibrosarcoma-like tumor.

Karen Schoedel, Shaymaa Hegazy, Megan L Zilla, Jason Chang, Benjamin A Nacev

Erratum issuedAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Karen SchoedelDepartment of Pathology, University of Pittsburgh, UPMC Presbyterian C602, 200 Lothrop St., Pittsburgh, PA, 15213, USA. schoedelke@upmc.edu.ORCID http://orcid.org/0000-0001-5398-8962
Shaymaa HegazyDepartment of Pathology, University of Pittsburgh, UPMC Presbyterian C602, 200 Lothrop St., Pittsburgh, PA, 15213, USA.
Megan L ZillaDepartment of Pathology, University of Pittsburgh, UPMC Presbyterian C602, 200 Lothrop St., Pittsburgh, PA, 15213, USA.
Jason ChangMemorial Sloan Kettering Cancer Center, New York, NY, USA.
Benjamin A NacevDepartment of Pathology, University of Pittsburgh, UPMC Presbyterian C602, 200 Lothrop St., Pittsburgh, PA, 15213, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 1988 to 2026
$158.0M
NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA047904
6 · The paper itself

Abstract

The list of potential gene fusions involving sarcomas, and particularly infantile fibrosarcoma-like tumors, continues to expand. The receptor tyrosine kinases are dysregulated in several tumor types, underscoring their roles in neoplasia. In this case presentation, we describe a pulmonary metastasis with two novel gene fusions (FKBP5::PRKCA and in-frame SEPT7::RAF1) occurring at least two decades after the primary tumor developed.

Indexed as

Biomarkers, TumorFibrosarcomaGene FusionLung NeoplasmsHumansOncogene Proteins, FusionSeptinsBiomarkers, TumorOncogene Proteins, FusionSeptinsGene fusionInfantile fibrosarcomaNext generation sequencing

Identifiers

PMID39078429
PMCPMC11779980

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.