Evidence map›Paper›PMID 39078404›Full record

ArticleJournal of the American Society of Nephrology : JASN2024

Klotho: A Large Protein with Various Beneficial Functions, but also with Therapeutic Value?

Christopher Yanucil, Christian Faul

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Christopher YanucilAlpha Young LLC, Carlsbad, California.
Christian FaulDivision of Nephrology and Section of Mineral Metabolism, Department of Medicine, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama.ORCID 0000-0002-7512-0977

Funding

Changes in phosphate metabolism cause pathologic cardiac remodeling in chronic kidney disease (CKD)R01HL145528 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI FAUL, CHRISTIAN, WHITE, KENNETH E · 2019 to 2022
$2.4M
Design of a bioactive mimetic of soluble klotho for the treatment of chronic kidney diseaseR44DK132996 · NIDDK · ALPHA YOUNG LLC · PI YANUCIL, CHRISTOPHER · 2022 to 2025
$2.0M
Vitamin D and soluble Klotho inhibit FGF23-mediated cardiac hypertrophy in Chronic Kidney DiseaseF31DK115074 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YANUCIL, CHRISTOPHER · 2017 to 2019
$106k
NHLBI NIH HHS R01 HL145528NHLBI NIH HHS R01HL145528NIDDK NIH HHS F31 DK115074NIDDK NIH HHS F31DK115074NIDDK NIH HHS R44 DK132996NIDDK NIH HHS R44DK132996
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

cardiovascular diseasecell signalingCKDheart diseasevascular calcification

Identifiers

PMID39078404
PMCPMC11387019

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.