Evidence map›Paper›PMID 39078314›Full record

ArticleNutrition and cancer2024

Effects of Antioxidant Dietary Supplement Use upon Response to Cancer Treatment: A Scoping Review of Available Evidence.

L Susan Wieland, Sydney Shade, Ilana Moffet, Amir Ansari, Ashkan Emadi, Cheryl L Knott, Emily F Gorman, Christopher R D'Adamo

Abstract readScoping Review
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrition and cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Redox Control in Platelet Activity and Therapy.Antioxidants (Basel, Switzerland) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

L Susan WielandDepartment of Family and Community Medicine, Center for Integrative Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-2157-0603
Sydney ShadeGeisinger Commonwealth School of Medicine, Scranton, Pennsylvania, USA.ORCID 0000-0002-4672-6873
Ilana MoffetUniversity of Michigan College of Literature, Ann Arbor, Michigan, USA.
Amir AnsariUniversity of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, Maryland, USA.
Ashkan EmadiDepartment of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-3769-3210
Cheryl L KnottUniversity of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, Maryland, USA.ORCID 0000-0002-2261-7875
Emily F GormanHealth Sciences and Human Services Library, University of Maryland, Baltimore, Maryland, USA.ORCID 0000-0002-1210-1082
Christopher R D'AdamoDepartment of Family and Community Medicine, Center for Integrative Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-2415-8158

Funding

UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANTP30CA134274 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI Taofeek K Owonikoko · 2008 to 2026
$51.0M
Cochrane Complementary Medicine Field: Resource for ResearchR24AT001293 · NCCIH · UNIVERSITY OF MARYLAND BALTIMORE · PI BERMAN, BRIAN M, WIELAND, LISA SUSAN · 2003 to 2022
$9.4M
NCCIH NIH HHS R24 AT001293NCI NIH HHS P30 CA134274
6 · The paper itself

Abstract

introductionThe effects of antioxidant dietary supplements on response to biological therapies for cancer is unknown. We conducted a scoping review of the available systematic review evidence on this question. METHODS AND ANALYSIS: We searched six databases from inception to August 19, 2022 for systematic reviews of randomized controlled trials of antioxidant dietary supplements used by patients receiving curative chemotherapy, radiotherapy, or other biological therapy for cancer and assessing the impact of supplements on survival, treatment response, or disease progression. We focused on results from reviews at high or moderate AMSTAR-2 quality. Records were selected, data extracted, and AMSTAR-2 ratings assessed independently by two authors.

resultsWe found 24 systematic reviews with relevant evidence. Reviews were heterogenous in cancers, treatments, and antioxidant dietary supplements assessed. Conclusions across reviews were mixed, ranging from negative to no apparent difference to positive, but always with caveats about the limited size and quality of the evidence. One review was rated 'moderate' on AMSTAR-2; it included one small trial of vitamin C and formed no firm conclusions.

conclusionsWe did not find reliable systematic review evidence on the effects of antioxidant dietary supplements upon therapies for cancer. More research is necessary to inform clinical recommendations.

Indexed as

AntioxidantsDietary SupplementsNeoplasmsHumansRandomized Controlled Trials as TopicTreatment OutcomeAntioxidants

Identifiers

PMID39078314
PMCPMC11419937

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.