ArticleRadiology2024
Overestimation of the Ischemic Core Is Associated With Higher Core Lesion Volume and Degree of Reperfusion After Thrombectomy.
Abstract readMulticenter Study
In one paragraph
Article in Radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5citing papers in PubMed
–field-weighted citation impact
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Oedema reduction mediates thrombectomy benefit in large core stroke: secondary analysis of the TENSION trial.European stroke journal · 2026Trial
- Mediation of ghost infarct core on prognosis by venous outflow and net water uptake after stroke thrombectomy.European radiology · 2026Article
- Comparison of CT-perfusion software packages and validation with true infarct core in patients with acute ischemic stroke.BMC medical imaging · 2025Article
- Ct-Perfusion Absolute Ghost Infarct Core Is a Rare Phenomenon Associated with Poor Collateral Status in Acute Ischemic Stroke Patients.Journal of clinical medicine · 2025Article
- Net water uptake and ASPECTS in predicting futile recanalization for acute large vessel occlusion stroke: insights from time window stratification.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
17 authors.
Gabriel BroocksFrom the Department of Neuroradiology (G.B., L.M., L.W., H.K., C.H., C.T., J.F., T.D.F.) and Institute for Medical Biometry and Epidemiology (G.S.), University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany; Department of Neuroradiology, HELIOS Medical Center, Campus of MSH Medical School Hamburg, Schwerin, Germany (G.B.); Departments of Neurology and Neurologic Sciences (S.C., M.G.L., M.W.) and Radiology (G.A., J.J.H.), Stanford University School of Medicine, Stanford, Calif; Department of Neuroradiology, University of Marburg, Marburg, Germany (A.K.); Department of Radiology, Comenius University's Jessenius Faculty of Medicine and University Hospital, Martin, Slovakia (K.Z.); and Department of Neuroradiology, University Hospital Münster, Münster, Germany (P.C.S., T.D.F.).ORCID 0000-0002-7575-9850
Lukas MeyerFrom the Department of Neuroradiology (G.B., L.M., L.W., H.K., C.H., C.T., J.F., T.D.F.) and Institute for Medical Biometry and Epidemiology (G.S.), University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany; Department of Neuroradiology, HELIOS Medical Center, Campus of MSH Medical School Hamburg, Schwerin, Germany (G.B.); Departments of Neurology and Neurologic Sciences (S.C., M.G.L., M.W.) and Radiology (G.A., J.J.H.), Stanford University School of Medicine, Stanford, Calif; Department of Neuroradiology, University of Marburg, Marburg, Germany (A.K.); Department of Radiology, Comenius University's Jessenius Faculty of Medicine and University Hospital, Martin, Slovakia (K.Z.); and Department of Neuroradiology, University Hospital Münster, Münster, Germany (P.C.S., T.D.F.).ORCID 0000-0002-3776-638X
Laurens WinkelmeierFrom the Department of Neuroradiology (G.B., L.M., L.W., H.K., C.H., C.T., J.F., T.D.F.) and Institute for Medical Biometry and Epidemiology (G.S.), University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany; Department of Neuroradiology, HELIOS Medical Center, Campus of MSH Medical School Hamburg, Schwerin, Germany (G.B.); Departments of Neurology and Neurologic Sciences (S.C., M.G.L., M.W.) and Radiology (G.A., J.J.H.), Stanford University School of Medicine, Stanford, Calif; Department of Neuroradiology, University of Marburg, Marburg, Germany (A.K.); Department of Radiology, Comenius University's Jessenius Faculty of Medicine and University Hospital, Martin, Slovakia (K.Z.); and Department of Neuroradiology, University Hospital Münster, Münster, Germany (P.C.S., T.D.F.).ORCID 0000-0002-9103-5983
Helge KniepFrom the Department of Neuroradiology (G.B., L.M., L.W., H.K., C.H., C.T., J.F., T.D.F.) and Institute for Medical Biometry and Epidemiology (G.S.), University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany; Department of Neuroradiology, HELIOS Medical Center, Campus of MSH Medical School Hamburg, Schwerin, Germany (G.B.); Departments of Neurology and Neurologic Sciences (S.C., M.G.L., M.W.) and Radiology (G.A., J.J.H.), Stanford University School of Medicine, Stanford, Calif; Department of Neuroradiology, University of Marburg, Marburg, Germany (A.K.); Department of Radiology, Comenius University's Jessenius Faculty of Medicine and University Hospital, Martin, Slovakia (K.Z.); and Department of Neuroradiology, University Hospital Münster, Münster, Germany (P.C.S., T.D.F.).ORCID 0000-0001-5258-2370
Christian HeitkampFrom the Department of Neuroradiology (G.B., L.M., L.W., H.K., C.H., C.T., J.F., T.D.F.) and Institute for Medical Biometry and Epidemiology (G.S.), University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany; Department of Neuroradiology, HELIOS Medical Center, Campus of MSH Medical School Hamburg, Schwerin, Germany (G.B.); Departments of Neurology and Neurologic Sciences (S.C., M.G.L., M.W.) and Radiology (G.A., J.J.H.), Stanford University School of Medicine, Stanford, Calif; Department of Neuroradiology, University of Marburg, Marburg, Germany (A.K.); Department of Radiology, Comenius University's Jessenius Faculty of Medicine and University Hospital, Martin, Slovakia (K.Z.); and Department of Neuroradiology, University Hospital Münster, Münster, Germany (P.C.S., T.D.F.).ORCID 0000-0002-8988-0918
Soren ChristensenFrom the Department of Neuroradiology (G.B., L.M., L.W., H.K., C.H., C.T., J.F., T.D.F.) and Institute for Medical Biometry and Epidemiology (G.S.), University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany; Department of Neuroradiology, HELIOS Medical Center, Campus of MSH Medical School Hamburg, Schwerin, Germany (G.B.); Departments of Neurology and Neurologic Sciences (S.C., M.G.L., M.W.) and Radiology (G.A., J.J.H.), Stanford University School of Medicine, Stanford, Calif; Department of Neuroradiology, University of Marburg, Marburg, Germany (A.K.); Department of Radiology, Comenius University's Jessenius Faculty of Medicine and University Hospital, Martin, Slovakia (K.Z.); and Department of Neuroradiology, University Hospital Münster, Münster, Germany (P.C.S., T.D.F.).ORCID 0000-0003-1242-3724
Maarten G LansbergFrom the Department of Neuroradiology (G.B., L.M., L.W., H.K., C.H., C.T., J.F., T.D.F.) and Institute for Medical Biometry and Epidemiology (G.S.), University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany; Department of Neuroradiology, HELIOS Medical Center, Campus of MSH Medical School Hamburg, Schwerin, Germany (G.B.); Departments of Neurology and Neurologic Sciences (S.C., M.G.L., M.W.) and Radiology (G.A., J.J.H.), Stanford University School of Medicine, Stanford, Calif; Department of Neuroradiology, University of Marburg, Marburg, Germany (A.K.); Department of Radiology, Comenius University's Jessenius Faculty of Medicine and University Hospital, Martin, Slovakia (K.Z.); and Department of Neuroradiology, University Hospital Münster, Münster, Germany (P.C.S., T.D.F.).ORCID 0000-0002-3545-6927
Christian ThalerFrom the Department of Neuroradiology (G.B., L.M., L.W., H.K., C.H., C.T., J.F., T.D.F.) and Institute for Medical Biometry and Epidemiology (G.S.), University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany; Department of Neuroradiology, HELIOS Medical Center, Campus of MSH Medical School Hamburg, Schwerin, Germany (G.B.); Departments of Neurology and Neurologic Sciences (S.C., M.G.L., M.W.) and Radiology (G.A., J.J.H.), Stanford University School of Medicine, Stanford, Calif; Department of Neuroradiology, University of Marburg, Marburg, Germany (A.K.); Department of Radiology, Comenius University's Jessenius Faculty of Medicine and University Hospital, Martin, Slovakia (K.Z.); and Department of Neuroradiology, University Hospital Münster, Münster, Germany (P.C.S., T.D.F.).ORCID 0000-0002-7102-9316
Andre KemmlingFrom the Department of Neuroradiology (G.B., L.M., L.W., H.K., C.H., C.T., J.F., T.D.F.) and Institute for Medical Biometry and Epidemiology (G.S.), University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany; Department of Neuroradiology, HELIOS Medical Center, Campus of MSH Medical School Hamburg, Schwerin, Germany (G.B.); Departments of Neurology and Neurologic Sciences (S.C., M.G.L., M.W.) and Radiology (G.A., J.J.H.), Stanford University School of Medicine, Stanford, Calif; Department of Neuroradiology, University of Marburg, Marburg, Germany (A.K.); Department of Radiology, Comenius University's Jessenius Faculty of Medicine and University Hospital, Martin, Slovakia (K.Z.); and Department of Neuroradiology, University Hospital Münster, Münster, Germany (P.C.S., T.D.F.).ORCID 0000-0001-8930-1894
Gerhard SchönFrom the Department of Neuroradiology (G.B., L.M., L.W., H.K., C.H., C.T., J.F., T.D.F.) and Institute for Medical Biometry and Epidemiology (G.S.), University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany; Department of Neuroradiology, HELIOS Medical Center, Campus of MSH Medical School Hamburg, Schwerin, Germany (G.B.); Departments of Neurology and Neurologic Sciences (S.C., M.G.L., M.W.) and Radiology (G.A., J.J.H.), Stanford University School of Medicine, Stanford, Calif; Department of Neuroradiology, University of Marburg, Marburg, Germany (A.K.); Department of Radiology, Comenius University's Jessenius Faculty of Medicine and University Hospital, Martin, Slovakia (K.Z.); and Department of Neuroradiology, University Hospital Münster, Münster, Germany (P.C.S., T.D.F.).ORCID 0000-0003-2556-6804
Kamil ZeleňákFrom the Department of Neuroradiology (G.B., L.M., L.W., H.K., C.H., C.T., J.F., T.D.F.) and Institute for Medical Biometry and Epidemiology (G.S.), University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany; Department of Neuroradiology, HELIOS Medical Center, Campus of MSH Medical School Hamburg, Schwerin, Germany (G.B.); Departments of Neurology and Neurologic Sciences (S.C., M.G.L., M.W.) and Radiology (G.A., J.J.H.), Stanford University School of Medicine, Stanford, Calif; Department of Neuroradiology, University of Marburg, Marburg, Germany (A.K.); Department of Radiology, Comenius University's Jessenius Faculty of Medicine and University Hospital, Martin, Slovakia (K.Z.); and Department of Neuroradiology, University Hospital Münster, Münster, Germany (P.C.S., T.D.F.).ORCID 0000-0002-0416-2985
Paul C StrackeFrom the Department of Neuroradiology (G.B., L.M., L.W., H.K., C.H., C.T., J.F., T.D.F.) and Institute for Medical Biometry and Epidemiology (G.S.), University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany; Department of Neuroradiology, HELIOS Medical Center, Campus of MSH Medical School Hamburg, Schwerin, Germany (G.B.); Departments of Neurology and Neurologic Sciences (S.C., M.G.L., M.W.) and Radiology (G.A., J.J.H.), Stanford University School of Medicine, Stanford, Calif; Department of Neuroradiology, University of Marburg, Marburg, Germany (A.K.); Department of Radiology, Comenius University's Jessenius Faculty of Medicine and University Hospital, Martin, Slovakia (K.Z.); and Department of Neuroradiology, University Hospital Münster, Münster, Germany (P.C.S., T.D.F.).ORCID 0000-0003-1242-4372
Gregory AlbersFrom the Department of Neuroradiology (G.B., L.M., L.W., H.K., C.H., C.T., J.F., T.D.F.) and Institute for Medical Biometry and Epidemiology (G.S.), University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany; Department of Neuroradiology, HELIOS Medical Center, Campus of MSH Medical School Hamburg, Schwerin, Germany (G.B.); Departments of Neurology and Neurologic Sciences (S.C., M.G.L., M.W.) and Radiology (G.A., J.J.H.), Stanford University School of Medicine, Stanford, Calif; Department of Neuroradiology, University of Marburg, Marburg, Germany (A.K.); Department of Radiology, Comenius University's Jessenius Faculty of Medicine and University Hospital, Martin, Slovakia (K.Z.); and Department of Neuroradiology, University Hospital Münster, Münster, Germany (P.C.S., T.D.F.).ORCID 0000-0003-0263-4632
Jens FiehlerFrom the Department of Neuroradiology (G.B., L.M., L.W., H.K., C.H., C.T., J.F., T.D.F.) and Institute for Medical Biometry and Epidemiology (G.S.), University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany; Department of Neuroradiology, HELIOS Medical Center, Campus of MSH Medical School Hamburg, Schwerin, Germany (G.B.); Departments of Neurology and Neurologic Sciences (S.C., M.G.L., M.W.) and Radiology (G.A., J.J.H.), Stanford University School of Medicine, Stanford, Calif; Department of Neuroradiology, University of Marburg, Marburg, Germany (A.K.); Department of Radiology, Comenius University's Jessenius Faculty of Medicine and University Hospital, Martin, Slovakia (K.Z.); and Department of Neuroradiology, University Hospital Münster, Münster, Germany (P.C.S., T.D.F.).ORCID 0000-0001-8533-7478
Max WintermarkFrom the Department of Neuroradiology (G.B., L.M., L.W., H.K., C.H., C.T., J.F., T.D.F.) and Institute for Medical Biometry and Epidemiology (G.S.), University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany; Department of Neuroradiology, HELIOS Medical Center, Campus of MSH Medical School Hamburg, Schwerin, Germany (G.B.); Departments of Neurology and Neurologic Sciences (S.C., M.G.L., M.W.) and Radiology (G.A., J.J.H.), Stanford University School of Medicine, Stanford, Calif; Department of Neuroradiology, University of Marburg, Marburg, Germany (A.K.); Department of Radiology, Comenius University's Jessenius Faculty of Medicine and University Hospital, Martin, Slovakia (K.Z.); and Department of Neuroradiology, University Hospital Münster, Münster, Germany (P.C.S., T.D.F.).ORCID 0000-0002-6726-3951
Jeremy J HeitFrom the Department of Neuroradiology (G.B., L.M., L.W., H.K., C.H., C.T., J.F., T.D.F.) and Institute for Medical Biometry and Epidemiology (G.S.), University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany; Department of Neuroradiology, HELIOS Medical Center, Campus of MSH Medical School Hamburg, Schwerin, Germany (G.B.); Departments of Neurology and Neurologic Sciences (S.C., M.G.L., M.W.) and Radiology (G.A., J.J.H.), Stanford University School of Medicine, Stanford, Calif; Department of Neuroradiology, University of Marburg, Marburg, Germany (A.K.); Department of Radiology, Comenius University's Jessenius Faculty of Medicine and University Hospital, Martin, Slovakia (K.Z.); and Department of Neuroradiology, University Hospital Münster, Münster, Germany (P.C.S., T.D.F.).ORCID 0000-0002-1058-1393
Tobias D FaizyFrom the Department of Neuroradiology (G.B., L.M., L.W., H.K., C.H., C.T., J.F., T.D.F.) and Institute for Medical Biometry and Epidemiology (G.S.), University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany; Department of Neuroradiology, HELIOS Medical Center, Campus of MSH Medical School Hamburg, Schwerin, Germany (G.B.); Departments of Neurology and Neurologic Sciences (S.C., M.G.L., M.W.) and Radiology (G.A., J.J.H.), Stanford University School of Medicine, Stanford, Calif; Department of Neuroradiology, University of Marburg, Marburg, Germany (A.K.); Department of Radiology, Comenius University's Jessenius Faculty of Medicine and University Hospital, Martin, Slovakia (K.Z.); and Department of Neuroradiology, University Hospital Münster, Münster, Germany (P.C.S., T.D.F.).ORCID 0000-0002-1631-2020
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background CT perfusion (CTP)-derived baseline ischemic core volume (ICV) can overestimate the true extent of infarction, which may result in exclusion of patients with ischemic stroke from endovascular treatment (EVT). Purpose To determine whether ischemic core overestimation is associated with larger ICV and degree of recanalization. Materials and Methods This retrospective multicenter cohort study included patients with acute ischemic stroke triaged at multimodal CT who underwent EVT between January 2015 and January 2022. The primary outcome was ischemic core overestimation, which was assumed when baseline CTP-derived ICV was larger than the final infarct volume at follow-up imaging. The secondary outcome was functional independence defined as modified Rankin Scale scores of 0-2 90 days after EVT. Successful vessel recanalization was defined as extended Thrombolysis in Cerebral Infarction score of 2b or higher. Categorical variables were compared between patients with ICV of 50 mL or less versus large ICV greater than 50 mL with use of the χ
Indexed as
Ischemic StrokeReperfusionThrombectomyAgedAged, 80 and overFemaleHumansMaleMiddle AgedRetrospective StudiesTomography, X-Ray ComputedTreatment Outcome
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