Evidence map›Paper›PMID 39077756›Full record

ReviewFrontiers in molecular neuroscience2024

The roles of circular RNAs in nerve injury and repair.

Ying Zong, Yuqi Dai, Junjie Yan, Bin Yu, Dong Wang, Susu Mao

Abstract readReview
In one paragraph

Review in Frontiers in molecular neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ying Zong *Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, School of Medicine, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China.
Yuqi Dai *Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, School of Medicine, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China.
Junjie YanKey Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, School of Medicine, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China.
Bin YuKey Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, School of Medicine, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China.
Dong WangKey Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, School of Medicine, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China.
Susu MaoKey Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, School of Medicine, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nerve injuries significantly impact the quality of life for patients, with severe cases posing life-threatening risks. A comprehensive understanding of the pathophysiological mechanisms underlying nerve injury is crucial to the development of effective strategies to promote nerve regeneration. Circular RNAs (circRNAs), a recently characterized class of RNAs distinguished by their covalently closed-loop structures, have been shown to play an important role in various biological processes. Numerous studies have highlighted the pivotal role of circRNAs in nerve regeneration, identifying them as potential therapeutic targets. This review aims to succinctly outline the latest advances in the role of circRNAs related to nerve injury repair and the underlying mechanisms, including peripheral nerve injury, traumatic brain injury, spinal cord injury, and neuropathic pain. Finally, we discuss the potential applications of circRNAs in drug development and consider the potential directions for future research in this field to provide insights into circRNAs in nerve injury repair.

Indexed as

circular RNAnerve regenerationneuropathic painperipheral nerve injuryspinal cord injurytraumatic brain injury

Identifiers

PMID39077756
PMCPMC11284605

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.