SynthesisReviews in cardiovascular medicine2022
Hyperuricemia and Gout are Associated with the Risk of Atrial Fibrillation: An Updated Meta-Analysis.
Synthesis in Reviews in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Are Machine Learning methods effective in detecting undiagnosed atrial fibrillation in primary care settings using electronic health records? A systematic review.PLOS digital health · 2025Article
- Causal association between common rheumatic diseases and arrhythmia: a Mendelian randomization study.Frontiers in cardiovascular medicine · 2024Article
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Authors and funding
10 authors.
Funding
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Abstract
Background: Although it has been suggested that hyperuricemia and gout are predictive of the future risk of atrial fibrillation, there is still a lack of epidemiological evidence. Objective: Through an updated systematic review and meta-analysis, we aimed to assess the association between hyperuricemia/gout and atrial fibrillation. Methods: We performed a systematic search of EMBASE, PubMed, and Web of Science from their establishment to September 2021 for all relevant studies of hyperuricemia or gout and atrial fibrillation. Meta-analysis was conducted using the random-effects method to calculate the overall relative risk (RR) and 95% confidence intervals (CI), and subgroup analyses were performed on data subsets by geographic location and study design. Result: A total of 12 studies were included in this study. The results from 8 studies showed that hyperuricemia was associated with an increased incidence of atrial fibrillation (RR: 1.83, 95% CI: 1.35-2.47), but significant association was only observed in studies in China (RR: 1.88, 95% CI: 1.31-2.71) and cross-sectional studies (RR: 2.35, 95% CI: 1.97-2.81) rather than studies in Japan (RR: 1.74, 95% CI: 0.71-4.23) and cohort studies (RR: 1.20, 95% CI: 0.99-1.46). The results from 4 studies showed that gout was also associated with an increased risk of AF (RR: 1.33, 95% CI: 1.04-1.71). Conclusions: Hyperuricemia and gout are associated with an increased incidence of atrial fibrillation.
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